CRCGN015_MCF10A.WT.HP_24H:B11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfuric acid compound with 2-methyl-1,4-benzenediamine (1:1) 33.45 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

121 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:B11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 5.14304
PRR7 proline rich 7 (synaptic) 4.07709
KLHL21 kelch-like family member 21 3.7625
GLRX glutaredoxin (thioltransferase) 3.52308
ADGRE5 adhesion G protein-coupled receptor E5 3.43989
CANT1 calcium activated nucleotidase 1 3.3993
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.33573
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.27822
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.25262
HYOU1 hypoxia up-regulated 1 3.12532
CISD1 CDGSH iron sulfur domain 1 2.88739
NUCB2 nucleobindin 2 2.84175
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.7939
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.78368
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.76021
CTSL cathepsin L 2.74331
RAI14 retinoic acid induced 14 2.73432
IL1B interleukin 1, beta 2.71871
SLC67A1 solute carrier family 67 member 1 2.56677
GPC1 glypican 1 2.47365
ZNF589 zinc finger protein 589 2.45194
CDPF1 cysteine-rich, DPF motif domain containing 1 2.43779
SNAI2 snail family zinc finger 2 2.42858
SQOR sulfide quinone oxidoreductase 2.42446
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.32252
CADM1 cell adhesion molecule 1 2.30925
LCE2B late cornified envelope 2B 2.29552
CEMIP2 cell migration inducing hyaluronidase 2 2.28075
CAMTA2 calmodulin binding transcription activator 2 2.2695
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.25792
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa 2.25345
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.23262
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.22897
HMOX1 heme oxygenase 1 2.15125
GARRE1 granule associated Rac and RHOG effector 1 2.13851
IGHMBP2 immunoglobulin mu binding protein 2 2.13471
LOC102724023 ES1 protein homolog, mitochondrial 2.1264
IL20RA interleukin 20 receptor, alpha 2.12528
OMD osteomodulin 2.10519
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.09168
MTA1 metastasis associated 1 2.08238
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.08181
RAP1GAP RAP1 GTPase activating protein 2.07793
FMO1 flavin containing monooxygenase 1 2.07491
CCNA1 cyclin A1 2.04878
SREK1IP1 SREK1-interacting protein 1 2.04079

decreased expression

Symbol Name Standardized Value
STMN1 stathmin 1 -5.20084
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.89598
CCNB2 cyclin B2 -4.68789
KIF14 kinesin family member 14 -4.39114
UBE2C ubiquitin-conjugating enzyme E2C -4.08434
TXNDC9 thioredoxin domain containing 9 -3.87197
TOP2A topoisomerase (DNA) II alpha 170kDa -3.66257
KDM3A lysine (K)-specific demethylase 3A -3.64942
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.55296
UBE3C ubiquitin protein ligase E3C -3.51424
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.40711
BASP1 brain abundant, membrane attached signal protein 1 -3.15789
KIF20A kinesin family member 20A -3.12686
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -3.12233
NLRP4 NLR family, pyrin domain containing 4 -3.10545
CD320 CD320 molecule -3.02135
UFM1 ubiquitin-fold modifier 1 -2.89347
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.84713
BIRC5 baculoviral IAP repeat containing 5 -2.82234
TUBB6 tubulin, beta 6 class V -2.76292
GNAS GNAS complex locus -2.73505
THAP11 THAP domain containing 11 -2.73229
NUSAP1 nucleolar and spindle associated protein 1 -2.71991
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.67002
CDK1 cyclin-dependent kinase 1 -2.5972
NCAPH non-SMC condensin I complex, subunit H -2.58489
CCNA2 cyclin A2 -2.56251
TPX2 TPX2, microtubule-associated -2.55729
RPA3 replication protein A3, 14kDa -2.52171
USP39 ubiquitin specific peptidase 39 -2.50414
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.48428
NCAPG2 non-SMC condensin II complex, subunit G2 -2.41659
CKAP2 cytoskeleton associated protein 2 -2.41483
MSMO1 methylsterol monooxygenase 1 -2.4086
RPL39L ribosomal protein L39-like -2.37684
DCK deoxycytidine kinase -2.35659
KIF23 kinesin family member 23 -2.33909
RACGAP1 Rac GTPase activating protein 1 -2.33853
TP53 tumor protein p53 -2.31232
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.26391
KIF4A kinesin family member 4A -2.25964
LBR lamin B receptor -2.22345
TTK TTK protein kinase -2.21031
HADH hydroxyacyl-CoA dehydrogenase -2.20936
CDKN3 cyclin-dependent kinase inhibitor 3 -2.20568
CHMP1A charged multivesicular body protein 1A -2.20028
FBXO5 F-box protein 5 -2.19543
NEK2 NIMA-related kinase 2 -2.18881
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.17204
HYAL2 hyaluronoglucosaminidase 2 -2.16924
LZTFL1 leucine zipper transcription factor-like 1 -2.16366
TUBA1C tubulin, alpha 1c -2.16355
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.16011
PSRC1 proline/serine-rich coiled-coil 1 -2.15922
FANCI Fanconi anemia, complementation group I -2.14041
CMC2 C-x(9)-C motif containing 2 -2.13847
CRY1 cryptochrome circadian clock 1 -2.12939
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.12237
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 -2.11442
CDC45 cell division cycle 45 -2.1049
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.09366
BCL7B B-cell CLL/lymphoma 7B -2.06857
KIF15 kinesin family member 15 -2.06305
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -2.04728
DDIT4 DNA-damage-inducible transcript 4 -2.03565
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.03516
NUP85 nucleoporin 85kDa -2.03356
TUBA1B tubulin, alpha 1b -2.03233
NFIL3 nuclear factor, interleukin 3 regulated -2.03187
CENPU centromere protein U -2.02849
AURKA aurora kinase A -2.01781
MCRS1 microspherule protein 1 -2.01724
PSIP1 PC4 and SFRS1 interacting protein 1 -2.00886
LY86 lymphocyte antigen 86 -2.00757
CDC20 cell division cycle 20 -2.00125