CRCGN015_MCF10A.WT.HP_24H:B12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfuric acid compound with 2-methyl-1,4-benzenediamine (1:1) 11.15 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

18 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:B12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 4.51986
RPL39L ribosomal protein L39-like 3.39019
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.8976
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.67524
CGRRF1 cell growth regulator with ring finger domain 1 2.53489
FZD7 frizzled class receptor 7 2.44803
CXCL3 chemokine (C-X-C motif) ligand 3 2.37408
TXNRD1 thioredoxin reductase 1 2.23485
TPD52L2 tumor protein D52-like 2 2.05589
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.00907

decreased expression

Symbol Name Standardized Value
KIF20A kinesin family member 20A -4.55607
PCCB propionyl CoA carboxylase, beta polypeptide -4.13239
CCNB1 cyclin B1 -3.86854
CHMP4B charged multivesicular body protein 4B -3.85767
NUSAP1 nucleolar and spindle associated protein 1 -2.62993
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.14093
TRAP1 TNF receptor-associated protein 1 -2.13459
RACGAP1 Rac GTPase activating protein 1 -2.04731