CRCGN015_MCF10A.WT.HP_24H:B17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description beta-naphthoflavone 33.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:B17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 6.57465
PPARG peroxisome proliferator-activated receptor gamma 4.62709
GATA2 GATA binding protein 2 4.0967
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.48944
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.02399
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.94318
CXCL3 chemokine (C-X-C motif) ligand 3 2.77064
ADAT1 adenosine deaminase, tRNA-specific 1 2.55162
HBA1 hemoglobin, alpha 1 2.49387
MOK MOK protein kinase 2.4689
NOSIP nitric oxide synthase interacting protein 2.1659
PIEZO1 piezo-type mechanosensitive ion channel component 1 2.0405

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -7.64344
VAT1 vesicle amine transport 1 -4.42607
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.69941
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.17786
RALGDS ral guanine nucleotide dissociation stimulator -2.98768
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.82905
PANK2 pantothenate kinase 2 -2.75553
TMEM230 transmembrane protein 230 -2.72735
REEP5 receptor accessory protein 5 -2.64849
ATRN attractin -2.53658
STXBP2 syntaxin binding protein 2 -2.51129
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.46887
GABARAPL1 GABA(A) receptor-associated protein like 1 -2.41931
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 -2.41077
MCM6 minichromosome maintenance complex component 6 -2.36952
SORBS3 sorbin and SH3 domain containing 3 -2.25772
MAVS mitochondrial antiviral signaling protein -2.25441
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.18731
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.14945
DYNLL1 dynein, light chain, LC8-type 1 -2.14548
EXOSC4 exosome component 4 -2.14111
RPA3 replication protein A3, 14kDa -2.09352
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) -2.0632
KIZ kizuna centrosomal protein -2.06302
CENPU centromere protein U -2.05182