CRCGN015_MCF10A.WT.HP_24H:B19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibenz(a,h)anthracene 98.59 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

94 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:B19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 7.08518
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.35791
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.50611
HDGFL3 HDGF like 3 3.98435
CNRIP1 cannabinoid receptor interacting protein 1 3.73902
STMN2 stathmin 2 3.67267
SV2B synaptic vesicle glycoprotein 2B 3.51199
RBBP5 retinoblastoma binding protein 5 3.41588
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.38331
MTA2 metastasis associated 1 family, member 2 3.35581
MDM4 MDM4, p53 regulator 3.3247
SYT1 synaptotagmin I 3.28728
SNAP91 synaptosomal-associated protein, 91kDa 3.22095
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 3.22
ABHD6 abhydrolase domain containing 6 3.15129
SYN1 synapsin I 3.09717
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.01934
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.94083
RPH3A rabphilin 3A 2.93482
CEPT1 choline/ethanolamine phosphotransferase 1 2.9317
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.92549
SQOR sulfide quinone oxidoreductase 2.89291
COMP cartilage oligomeric matrix protein 2.85847
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.84913
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.84314
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.84247
LGI1 leucine-rich, glioma inactivated 1 2.82804
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.82111
NSG2 neuronal vesicle trafficking associated 2 2.75491
GPER1 G protein-coupled estrogen receptor 1 2.74351
NUTF2 nuclear transport factor 2 2.73376
CARTPT CART prepropeptide 2.70296
TAGLN3 transgelin 3 2.69482
VSNL1 visinin-like 1 2.66463
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.65684
GSTK1 glutathione S-transferase kappa 1 2.65237
SULT4A1 sulfotransferase family 4A, member 1 2.65234
SCG2 secretogranin II 2.59518
TAC1 tachykinin, precursor 1 2.57563
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.57404
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.55993
SH3GL2 SH3-domain GRB2-like 2 2.53521
GDAP1 ganglioside induced differentiation associated protein 1 2.51889
SNCB synuclein, beta 2.46523
IFI6 interferon, alpha-inducible protein 6 2.4494
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 2.42019
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.41422
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.3452
IL1B interleukin 1, beta 2.29932
KIF5C kinesin family member 5C 2.29473
RUNDC3A RUN domain containing 3A 2.28869
LAMP5 lysosomal-associated membrane protein family, member 5 2.28009
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.24419
PCSK1 proprotein convertase subtilisin/kexin type 1 2.23474
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.21326
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2.20286
OSTF1 osteoclast stimulating factor 1 2.1916
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 2.17578
NEFM neurofilament, medium polypeptide 2.17472
CCNL1 cyclin L1 2.17361
MOG myelin oligodendrocyte glycoprotein 2.1599
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.15724
EBF2 early B-cell factor 2 2.1494
GNG4 guanine nucleotide binding protein (G protein), gamma 4 2.13781
VGLL4 vestigial-like family member 4 2.11285
NEFH neurofilament, heavy polypeptide 2.10466
CDC25B cell division cycle 25B 2.10006
NPTX1 neuronal pentraxin I 2.08094
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 2.07618
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.07301
SCG3 secretogranin III 2.06395
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.04582
WIF1 WNT inhibitory factor 1 2.04108
STRN3 striatin, calmodulin binding protein 3 2.04082
PDYN prodynorphin 2.03627
HP1BP3 heterochromatin protein 1, binding protein 3 2.03575
SRSF6 serine/arginine-rich splicing factor 6 2.03534
THRAP3 thyroid hormone receptor associated protein 3 2.01341
ZNF286A zinc finger protein 286A 2.00596
MED18 mediator complex subunit 18 2.00591

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -5.2282
THAP11 THAP domain containing 11 -3.41781
TSPAN4 tetraspanin 4 -3.3773
SLC35F2 solute carrier family 35, member F2 -2.77444
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.65299
PCCB propionyl CoA carboxylase, beta polypeptide -2.64031
CD44 CD44 molecule (Indian blood group) -2.62077
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.575
EXOSC8 exosome component 8 -2.51212
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.20014
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.12536
ESD esterase D -2.08117
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -2.05004
MLH1 mutL homolog 1 -2.00959