CRCGN015_MCF10A.WT.HP_24H:B23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 34.95 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:B23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 4.15882
MSRA methionine sulfoxide reductase A 3.93348
SSBP2 single-stranded DNA binding protein 2 2.89649
SQOR sulfide quinone oxidoreductase 2.87343
PNKP polynucleotide kinase 3'-phosphatase 2.83627
TBPL1 TBP-like 1 2.70241
EGR1 early growth response 1 2.68872
HMGA2 high mobility group AT-hook 2 2.66912
COMP cartilage oligomeric matrix protein 2.66502
GSK3B glycogen synthase kinase 3 beta 2.64749
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.61431
KDM5A lysine (K)-specific demethylase 5A 2.50272
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.46564
SYNGAP1 synaptic Ras GTPase activating protein 1 2.44977
MOK MOK protein kinase 2.38587
DVL1 dishevelled segment polarity protein 1 2.3848
CNRIP1 cannabinoid receptor interacting protein 1 2.30053
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.26654
FHOD1 formin homology 2 domain containing 1 2.18627
CENPB centromere protein B, 80kDa 2.17888
DUSP6 dual specificity phosphatase 6 2.17659
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.1744
SSH1 slingshot protein phosphatase 1 2.1635
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.15939
EVL Enah/Vasp-like 2.1315
NPM3 nucleophosmin/nucleoplasmin 3 2.11111
UBA1 ubiquitin-like modifier activating enzyme 1 2.09797
MLPH melanophilin 2.09502
CTNNBIP1 catenin, beta interacting protein 1 2.07878
EGR3 early growth response 3 2.07056
RPIA ribose 5-phosphate isomerase A 2.06502

decreased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 -5.59765
COG7 component of oligomeric golgi complex 7 -3.89307
FAIM Fas apoptotic inhibitory molecule -3.72091
UFM1 ubiquitin-fold modifier 1 -3.57359
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.14934
REEP5 receptor accessory protein 5 -3.00297
PRR15L proline rich 15-like -2.95338
ALDOC aldolase C, fructose-bisphosphate -2.9142
MSMO1 methylsterol monooxygenase 1 -2.8928
GADD45B growth arrest and DNA-damage-inducible, beta -2.87987
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.71727
BAG1 BCL2-associated athanogene -2.53222
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.50335
ZNF426 zinc finger protein 426 -2.43009
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.39546
CD81 CD81 molecule -2.25291
RBM34 RNA binding motif protein 34 -2.23437
DNM1L dynamin 1-like -2.22091
CREG1 cellular repressor of E1A-stimulated genes 1 -2.21929
UNC119B unc-119 homolog B (C. elegans) -2.20852
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.20406
ARID4B AT rich interactive domain 4B (RBP1-like) -2.19483
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.15046
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -2.13485
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -2.10966
DENND5B DENN/MADD domain containing 5B -2.10355
SCGB1D1 secretoglobin, family 1D, member 1 -2.06516
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.06296
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -2.06129
ZNF268 zinc finger protein 268 -2.05141
IFRD2 interferon-related developmental regulator 2 -2.05044
ATF7IP2 activating transcription factor 7 interacting protein 2 -2.02984
CCL4 chemokine (C-C motif) ligand 4 -2.02982
SKAP2 src kinase associated phosphoprotein 2 -2.01861
PTPRR protein tyrosine phosphatase, receptor type, R -2.01832
ADRB2 adrenoceptor beta 2, surface -2.01554
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.01441
UBFD1 ubiquitin family domain containing 1 -2.00306