CRCGN015_MCF10A.WT.HP_24H:B24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 11.65 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:B24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 4.10537
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.27715
PDIA5 protein disulfide isomerase family A, member 5 3.14095
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.90847
PYCR1 pyrroline-5-carboxylate reductase 1 2.76693
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.45009
STMN2 stathmin 2 2.42749
CHEK1 checkpoint kinase 1 2.31755
TBXA2R thromboxane A2 receptor 2.22006
BLMH bleomycin hydrolase 2.17212
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.16882
ELP5 elongator acetyltransferase complex subunit 5 2.09801
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.09309
VSNL1 visinin-like 1 2.05221
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 2.04388
COQ8A coenzyme Q8A 2.01573

decreased expression

Symbol Name Standardized Value
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.37335
HMG20B high mobility group 20B -4.11086
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.80007
HSPA8 heat shock 70kDa protein 8 -3.68367
ALDOC aldolase C, fructose-bisphosphate -2.81895
HOXA5 homeobox A5 -2.60449
SGK1 serum/glucocorticoid regulated kinase 1 -2.3986
FBXO21 F-box protein 21 -2.31064
TMEM50A transmembrane protein 50A -2.20685
ARID4B AT rich interactive domain 4B (RBP1-like) -2.20276
OPRPN opiorphin prepropeptide -2.16481
CANT1 calcium activated nucleotidase 1 -2.11769
MSN moesin -2.08184
BHLHE41 basic helix-loop-helix family, member e41 -2.02342
LYPD1 LY6/PLAUR domain containing 1 -2.00654
ATP11B ATPase, class VI, type 11B -2.00475