CRCGN015_MCF10A.WT.HP_24H:C03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptamine 11.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:C03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MMP1 matrix metallopeptidase 1 3.64625
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.51987
C2CD2 C2 calcium-dependent domain containing 2 3.37248
STIMATE STIM activating enhancer 2.98052
CERK ceramide kinase 2.97928
ADGRE5 adhesion G protein-coupled receptor E5 2.89327
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.73238
ISOC1 isochorismatase domain containing 1 2.47816
ZNF586 zinc finger protein 586 2.30179
GRB7 growth factor receptor-bound protein 7 2.29154
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.28291
IGHMBP2 immunoglobulin mu binding protein 2 2.24072
ISG15 ISG15 ubiquitin-like modifier 2.20982
STX4 syntaxin 4 2.19943
SMIM40 small integral membrane protein 40 2.15773
ITFG1 integrin alpha FG-GAP repeat containing 1 2.11559
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.09257
FSD1 fibronectin type III and SPRY domain containing 1 2.07389

decreased expression

Symbol Name Standardized Value
PUF60 poly-U binding splicing factor 60KDa -3.87482
HMG20B high mobility group 20B -3.56053
MSN moesin -3.46394
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.35656
BASP1 brain abundant, membrane attached signal protein 1 -3.14554
OXA1L oxidase (cytochrome c) assembly 1-like -2.92744
COG4 component of oligomeric golgi complex 4 -2.64259
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.45006
CBR1 carbonyl reductase 1 -2.32124
TSPAN3 tetraspanin 3 -2.30817
ARID4B AT rich interactive domain 4B (RBP1-like) -2.26746
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.07696
TM9SF2 transmembrane 9 superfamily member 2 -2.0483
SIPA1L1 signal-induced proliferation-associated 1 like 1 -2.00859
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -2.00808
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -2.00446