CRCGN015_MCF10A.WT.HP_24H:C08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 15-delta-prostaglandin-j2 0.67 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:C08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EAPP E2F-associated phosphoprotein 6.59696
TXNRD1 thioredoxin reductase 1 6.46974
HMOX1 heme oxygenase 1 5.96404
TBX2 T-box 2 4.8653
SRP54 signal recognition particle 54kDa 3.88335
UGDH UDP-glucose 6-dehydrogenase 3.59026
CTSL cathepsin L 3.47212
CADM1 cell adhesion molecule 1 3.45101
ARHGAP5 Rho GTPase activating protein 5 3.26737
NUCB2 nucleobindin 2 2.91887
SCFD1 sec1 family domain containing 1 2.91235
SPTSSA serine palmitoyltransferase, small subunit A 2.89776
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.83129
SQSTM1 sequestosome 1 2.79407
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.70389
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.68076
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 2.58403
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.55893
AZU1 azurocidin 1 2.55199
GCLM glutamate-cysteine ligase, modifier subunit 2.51226
NQO1 NAD(P)H dehydrogenase, quinone 1 2.35297
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.29903
NUBP2 nucleotide binding protein 2 2.26462
CREB3L2 cAMP responsive element binding protein 3-like 2 2.25088
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.23811
PDIA5 protein disulfide isomerase family A, member 5 2.21787
PIR pirin (iron-binding nuclear protein) 2.2082
TMX2 thioredoxin-related transmembrane protein 2 2.19716
FMOD fibromodulin 2.16246
BSDC1 BSD domain containing 1 2.14417
GSR glutathione reductase 2.13945
TMEM248 transmembrane protein 248 2.13539
RBM6 RNA binding motif protein 6 2.09564
GLRX glutaredoxin (thioltransferase) 2.03419
ACIN1 apoptotic chromatin condensation inducer 1 2.0303
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.02838
MAIP1 matrix AAA peptidase interacting protein 1 2.01409
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.00632

decreased expression

Symbol Name Standardized Value
CD81 CD81 molecule -5.66387
MSMO1 methylsterol monooxygenase 1 -5.57996
MPC2 mitochondrial pyruvate carrier 2 -4.24871
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.03739
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.87777
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.48112
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.13204
HOXA5 homeobox A5 -3.0453
BAG3 BCL2-associated athanogene 3 -2.90694
S100A4 S100 calcium binding protein A4 -2.89164
NLRP4 NLR family, pyrin domain containing 4 -2.87129
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.77843
ISOC1 isochorismatase domain containing 1 -2.55754
TSPAN4 tetraspanin 4 -2.47973
RALGDS ral guanine nucleotide dissociation stimulator -2.44385
H2AC25 H2A clustered histone 25 -2.41221
MIDEAS mitotic deacetylase associated SANT domain protein -2.37581
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.23033
CRYZ crystallin, zeta (quinone reductase) -2.17161
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.0882
DPYSL2 dihydropyrimidinase-like 2 -2.08394
PCCA propionyl CoA carboxylase, alpha polypeptide -2.05895
AHCY adenosylhomocysteinase -2.05432
SPIN2B spindlin family, member 2B -2.03571
ARID4B AT rich interactive domain 4B (RBP1-like) -2.02034
ZNF276 zinc finger protein 276 -2.01631
RASA4 RAS p21 protein activator 4 -2.01519
SMYD2 SET and MYND domain containing 2 -2.00786
OXCT1 3-oxoacid CoA transferase 1 -2.00364