CRCGN015_MCF10A.WT.HP_24H:C10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cimetidine 99.96 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 5.07179
UBQLN2 ubiquilin 2 5.01952
KIF5C kinesin family member 5C 3.376
VGLL4 vestigial-like family member 4 3.07368
GRB10 growth factor receptor-bound protein 10 2.93949
ZNF589 zinc finger protein 589 2.87032
TENT4A terminal nucleotidyltransferase 4A 2.37974
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.33256
CPE carboxypeptidase E 2.22547
COMP cartilage oligomeric matrix protein 2.18916
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 2.10856
TDP2 tyrosyl-DNA phosphodiesterase 2 2.08579
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 2.05022
CDT1 chromatin licensing and DNA replication factor 1 2.02147
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 2.01204

decreased expression

Symbol Name Standardized Value
ACOT9 acyl-CoA thioesterase 9 -5.06697
UFM1 ubiquitin-fold modifier 1 -4.91188
FASTKD5 FAST kinase domains 5 -4.51809
PRPF4 pre-mRNA processing factor 4 -4.51452
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.41608
CCNB1 cyclin B1 -3.75536
HAT1 histone acetyltransferase 1 -3.68719
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -3.12021
CDC42SE1 CDC42 small effector 1 -2.54613
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.48125
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.47851
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.45135
SFXN1 sideroflexin 1 -2.45095
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.40904
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.37796
HEATR1 HEAT repeat containing 1 -2.30902
AP1S1 adaptor-related protein complex 1, sigma 1 subunit -2.29894
HSDL2 hydroxysteroid dehydrogenase like 2 -2.27902
DNAH7 dynein, axonemal, heavy chain 7 -2.27151
FAM131A family with sequence similarity 131, member A -2.23172
CGB8 chorionic gonadotropin, beta polypeptide 8 -2.21515
HABP4 hyaluronan binding protein 4 -2.20134
ERH enhancer of rudimentary homolog (Drosophila) -2.19452
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.1471
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.14663
TMED1 transmembrane emp24 protein transport domain containing 1 -2.1422
TCTN2 tectonic family member 2 -2.02056
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.01016