CRCGN015_MCF10A.WT.HP_24H:C11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cimetidine 33.32 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:C11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 5.79377
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 4.77929
CCL2 chemokine (C-C motif) ligand 2 4.6858
KDM5D lysine (K)-specific demethylase 5D 4.44622
USP9Y ubiquitin specific peptidase 9, Y-linked 4.28999
FCHO1 FCH domain only 1 3.89872
HBB hemoglobin, beta 3.80798
ZFY zinc finger protein, Y-linked 3.69002
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.42083
TLR4 toll-like receptor 4 3.32995
NLGN4Y neuroligin 4, Y-linked 2.88951
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.79561
ACAA1 acetyl-CoA acyltransferase 1 2.47936
CFI complement factor I 2.41994
RTP4 receptor (chemosensory) transporter protein 4 2.37957
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.35766
DUOX2 dual oxidase 2 2.30607
ART3 ADP-ribosyltransferase 3 2.29651
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.28722
VNN2 vanin 2 2.21504
DCN decorin 2.15788
GPR65 G protein-coupled receptor 65 2.12584
BCO1 beta-carotene oxygenase 1 2.1152
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.11231
GIMAP6 GTPase, IMAP family member 6 2.10973
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.06101
CBLIF cobalamin binding intrinsic factor 2.06086
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.04158
CCNC cyclin C 2.04101
FPR2 formyl peptide receptor 2 2.02822

decreased expression

Symbol Name Standardized Value
SMC1A structural maintenance of chromosomes 1A -3.85678
SLC35F2 solute carrier family 35, member F2 -3.63131
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -3.38088
COG7 component of oligomeric golgi complex 7 -3.37716
MAPK13 mitogen-activated protein kinase 13 -3.18896
PUDP pseudouridine 5'-phosphatase -2.84651
TRAPPC3 trafficking protein particle complex 3 -2.79825
KDM6A lysine (K)-specific demethylase 6A -2.69748
KDM5C lysine (K)-specific demethylase 5C -2.63536
UBA1 ubiquitin-like modifier activating enzyme 1 -2.61699
PSIP1 PC4 and SFRS1 interacting protein 1 -2.56664
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.53407
GDF15 growth differentiation factor 15 -2.39822
USP9X ubiquitin specific peptidase 9, X-linked -2.36048
PNPLA4 patatin-like phospholipase domain containing 4 -2.19889
STAMBP STAM binding protein -2.1893
SIX1 SIX homeobox 1 -2.13594
MRPS15 mitochondrial ribosomal protein S15 -2.09402
DNM1L dynamin 1-like -2.05395