CRCGN015_MCF10A.WT.HP_24H:C14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxyquinoline 33.82 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

127 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:C14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.25385
MAMLD1 mastermind-like domain containing 1 4.77872
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.69431
SPAG4 sperm associated antigen 4 4.59538
CXCL2 chemokine (C-X-C motif) ligand 2 4.49647
WIF1 WNT inhibitory factor 1 4.16018
INTS3 integrator complex subunit 3 3.65055
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.49021
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.22536
DHCR24 24-dehydrocholesterol reductase 2.82504
ACAA1 acetyl-CoA acyltransferase 1 2.71341
CNRIP1 cannabinoid receptor interacting protein 1 2.6929
NRBF2 nuclear receptor binding factor 2 2.69018
CRTAM cytotoxic and regulatory T cell molecule 2.58801
TCEA2 transcription elongation factor A (SII), 2 2.533
TMLHE trimethyllysine hydroxylase, epsilon 2.52562
COMP cartilage oligomeric matrix protein 2.50945
SYNPO2L synaptopodin 2-like 2.48144
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 2.42176
MTM1 myotubularin 1 2.3993
CXCL3 chemokine (C-X-C motif) ligand 3 2.39141
ZSCAN26 zinc finger and SCAN domain containing 26 2.38643
ZNF559-ZNF177 ZNF559-ZNF177 readthrough 2.38012
CLEC1A C-type lectin domain family 1, member A 2.3658
SMG9 SMG9 nonsense mediated mRNA decay factor 2.3588
CCNF cyclin F 2.35631
KAT2B K(lysine) acetyltransferase 2B 2.34219
DPYSL3 dihydropyrimidinase-like 3 2.32921
ACHE acetylcholinesterase (Yt blood group) 2.3022
GATA4 GATA binding protein 4 2.30041
CD1B CD1b molecule 2.2827
POPDC2 popeye domain containing 2 2.2767
IGSF3 immunoglobulin superfamily, member 3 2.25489
GRB10 growth factor receptor-bound protein 10 2.25393
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.25352
CCNA1 cyclin A1 2.25127
CD177 CD177 molecule 2.22985
ZNF223 zinc finger protein 223 2.21346
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 2.21192
MAGEA11 melanoma antigen family A11 2.21165
SCN7A sodium channel, voltage gated, type VII alpha subunit 2.20766
MSMB microseminoprotein, beta- 2.20458
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.18558
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2.17767
RYR2 ryanodine receptor 2 (cardiac) 2.17723
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 2.17692
LHX2 LIM homeobox 2 2.17365
GRN granulin 2.16728
CKM creatine kinase, muscle 2.16518
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.16263
BTNL2 butyrophilin-like 2 2.15206
MID2 midline 2 2.15122
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.14865
JCAD junctional cadherin 5 associated 2.13796
ANKH ANKH inorganic pyrophosphate transport regulator 2.13255
CAMTA1 calmodulin binding transcription activator 1 2.1319
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 2.12955
JHY junctional cadherin complex regulator 2.11943
MAB21L1 mab-21-like 1 (C. elegans) 2.10795
MCPH1 microcephalin 1 2.10467
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.10397
SUSD4 sushi domain containing 4 2.10178
JAG2 jagged 2 2.09827
ZFP30 ZFP30 zinc finger protein 2.08346
RIT2 Ras-like without CAAX 2 2.08015
MAGEA9B melanoma antigen family A9B 2.07375
TBCEL tubulin folding cofactor E-like 2.06793
CCDC88C coiled-coil domain containing 88C 2.06364
GSPT2 G1 to S phase transition 2 2.06274
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.05966
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.05949
KRT8 keratin 8, type II 2.05729
CHIT1 chitinase 1 (chitotriosidase) 2.05476
GRWD1 glutamate-rich WD repeat containing 1 2.04871
KRT38 keratin 38, type I 2.04802
ZNF426 zinc finger protein 426 2.03285
OXTR oxytocin receptor 2.02868
IRS4 insulin receptor substrate 4 2.02729
UROS uroporphyrinogen III synthase 2.02195
CHRM3 cholinergic receptor, muscarinic 3 2.01326
H2AJ H2A.J histone 2.01295
NXF2B nuclear RNA export factor 2B 2.011
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 2.0107
KLRG1 killer cell lectin-like receptor subfamily G, member 1 2.0016

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -5.10021
RNF167 ring finger protein 167 -4.96185
HMG20B high mobility group 20B -4.94474
WASHC4 WASH complex subunit 4 -4.88782
NPDC1 neural proliferation, differentiation and control, 1 -4.84327
TXNDC9 thioredoxin domain containing 9 -4.36313
UFM1 ubiquitin-fold modifier 1 -4.33705
MSN moesin -3.82211
HAT1 histone acetyltransferase 1 -3.75745
SPAG7 sperm associated antigen 7 -3.73989
MTFR1 mitochondrial fission regulator 1 -3.41769
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -3.02714
UNC50 unc-50 homolog (C. elegans) -2.68104
COX5B cytochrome c oxidase subunit Vb -2.57299
STAMBP STAM binding protein -2.56613
PFN1 profilin 1 -2.54197
CD81 CD81 molecule -2.47675
TMEM131 transmembrane protein 131 -2.47579
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -2.4113
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -2.40786
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -2.40091
LIPT1 lipoyltransferase 1 -2.37553
MRPL42 mitochondrial ribosomal protein L42 -2.37202
TP53RK TP53 regulating kinase -2.31226
OLA1 Obg-like ATPase 1 -2.30054
PRKACB protein kinase, cAMP-dependent, catalytic, beta -2.28675
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -2.2671
RPIA ribose 5-phosphate isomerase A -2.26289
SEC62 SEC62 homolog (S. cerevisiae) -2.24883
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.24759
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -2.22105
TKT transketolase -2.1643
HOXA10-HOXA9 HOXA10-HOXA9 readthrough -2.12754
GPBP1L1 GC-rich promoter binding protein 1-like 1 -2.11459
RPA3 replication protein A3, 14kDa -2.09275
CTDNEP1 CTD nuclear envelope phosphatase 1 -2.08648
ETFB electron-transfer-flavoprotein, beta polypeptide -2.08467
BARD1 BRCA1 associated RING domain 1 -2.07684
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -2.06728
EIF5B eukaryotic translation initiation factor 5B -2.06517
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial -2.04956
AFTPH aftiphilin -2.02775
GORASP2 golgi reassembly stacking protein 2, 55kDa -2.00875