CRCGN015_MCF10A.WT.HP_24H:C17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-nitronaphthalene 33.66 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:C17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 4.92587
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 3.63807
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.41596
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.26186
IGHMBP2 immunoglobulin mu binding protein 2 3.24465
IL1B interleukin 1, beta 2.95437
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.80044
THAP12 THAP domain containing 12 2.70297
FPGS folylpolyglutamate synthase 2.52003
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.425
SPOUT1 SPOUT domain containing methyltransferase 1 2.33111
TOR1A torsin family 1, member A (torsin A) 2.32668
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.24833
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.24263
PDIA5 protein disulfide isomerase family A, member 5 2.1266
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.1182
PRMT7 protein arginine methyltransferase 7 2.11746
CALML4 calmodulin-like 4 2.10948
DHRS11 dehydrogenase/reductase (SDR family) member 11 2.08989
PKN1 protein kinase N1 2.0769
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.04672
MGAM maltase-glucoamylase 2.03569
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.0268

decreased expression

Symbol Name Standardized Value
ACOT9 acyl-CoA thioesterase 9 -5.70859
TES testin LIM domain protein -4.7215
SCYL3 SCY1-like 3 (S. cerevisiae) -3.28197
GDF15 growth differentiation factor 15 -3.02724
ALDOC aldolase C, fructose-bisphosphate -2.82475
MTERF3 mitochondrial transcription termination factor 3 -2.72544
TIMP1 TIMP metallopeptidase inhibitor 1 -2.64231
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -2.61061
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.55355
MSMO1 methylsterol monooxygenase 1 -2.4164
APOO apolipoprotein O -2.40271
STAMBP STAM binding protein -2.34229
ARID4B AT rich interactive domain 4B (RBP1-like) -2.27919
ANXA2 annexin A2 -2.24792
CHIC2 cysteine-rich hydrophobic domain 2 -2.24563
RLF rearranged L-myc fusion -2.23395
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -2.11341
CAV1 caveolin 1, caveolae protein, 22kDa -2.10875
SLC39A2 solute carrier family 39 (zinc transporter), member 2 -2.08368
LRRC47 leucine rich repeat containing 47 -2.08092
PDCD6IP programmed cell death 6 interacting protein -2.02356