CRCGN015_MCF10A.WT.HP_24H:D01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description serotonin 100.0 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
COMP cartilage oligomeric matrix protein 6.1896
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 5.45155
SPAG4 sperm associated antigen 4 4.16174
EPHB2 EPH receptor B2 2.805
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.3836
REG1B regenerating islet-derived 1 beta 2.33421
CPA2 carboxypeptidase A2 (pancreatic) 2.26219
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.25445
REG3A regenerating islet-derived 3 alpha 2.24051
E2F2 E2F transcription factor 2 2.23903
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.14143
FAM117A family with sequence similarity 117, member A 2.11124
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 2.09231
SLC4A2 solute carrier family 4 (anion exchanger), member 2 2.04401
OLFM4 olfactomedin 4 2.04352
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.0391
NEO1 neogenin 1 2.0307

decreased expression

Symbol Name Standardized Value
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -7.26829
CD81 CD81 molecule -4.26614
FOS FBJ murine osteosarcoma viral oncogene homolog -3.87606
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.82357
COG7 component of oligomeric golgi complex 7 -3.81804
BAG3 BCL2-associated athanogene 3 -3.67408
VDAC1 voltage-dependent anion channel 1 -3.58901
REEP5 receptor accessory protein 5 -3.20742
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.1474
LYPLA1 lysophospholipase I -3.03923
ZNF430 zinc finger protein 430 -2.6963
MRPL30 mitochondrial ribosomal protein L30 -2.58709
PCYOX1 prenylcysteine oxidase 1 -2.4245
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.38286
CDK6 cyclin-dependent kinase 6 -2.30734
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.29695
GDE1 glycerophosphodiester phosphodiesterase 1 -2.28183
MSMO1 methylsterol monooxygenase 1 -2.2082
ZNF136 zinc finger protein 136 -2.18004
MRPL15 mitochondrial ribosomal protein L15 -2.17546
FOSB FBJ murine osteosarcoma viral oncogene homolog B -2.15311
TMEM47 transmembrane protein 47 -2.11668
EIF3I eukaryotic translation initiation factor 3, subunit I -2.11155
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.10715
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -2.08855
SNX24 sorting nexin 24 -2.04809
CREG1 cellular repressor of E1A-stimulated genes 1 -2.04674
TUFM Tu translation elongation factor, mitochondrial -2.03773
OXA1L oxidase (cytochrome c) assembly 1-like -2.03218
SREK1IP1 SREK1-interacting protein 1 -2.031
HEATR1 HEAT repeat containing 1 -2.01525