CRCGN015_MCF10A.WT.HP_24H:D04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fm550 perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MELK maternal embryonic leucine zipper kinase 3.04953
BAX BCL2-associated X protein 2.92181
ACAA1 acetyl-CoA acyltransferase 1 2.90803
CADM1 cell adhesion molecule 1 2.8781
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.60035
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.59835
S100A4 S100 calcium binding protein A4 2.57284
MCUR1 mitochondrial calcium uniporter regulator 1 2.54266
TRAM2 translocation associated membrane protein 2 2.40127
STK10 serine/threonine kinase 10 2.28029
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.22499
KDM5D lysine (K)-specific demethylase 5D 2.19701
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.17743
CGRRF1 cell growth regulator with ring finger domain 1 2.0867

decreased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 -4.97162
PARP2 poly (ADP-ribose) polymerase 2 -3.62201
CDC25B cell division cycle 25B -3.50185
CD81 CD81 molecule -3.04548
CREG1 cellular repressor of E1A-stimulated genes 1 -2.3446
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.07073
NPDC1 neural proliferation, differentiation and control, 1 -2.04324
CDKN2A cyclin-dependent kinase inhibitor 2A -2.0409
ZNF318 zinc finger protein 318 -2.02704
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.0106
NRIP1 nuclear receptor interacting protein 1 -2.0082