CRCGN015_MCF10A.WT.HP_24H:D05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fm550 perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IGHMBP2 immunoglobulin mu binding protein 2 6.12948
MCOLN1 mucolipin 1 5.51578
LAGE3 L antigen family, member 3 5.03221
KLHL21 kelch-like family member 21 4.76506
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.61676
SPAG4 sperm associated antigen 4 4.17503
GATA3 GATA binding protein 3 3.71967
BAMBI BMP and activin membrane-bound inhibitor 3.70627
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.34854
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.23847
TMX2 thioredoxin-related transmembrane protein 2 2.71492
ACAA1 acetyl-CoA acyltransferase 1 2.6102
SLC39A1 solute carrier family 39 (zinc transporter), member 1 2.60213
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.56793
BTK Bruton agammaglobulinemia tyrosine kinase 2.56311
THNSL2 threonine synthase-like 2 (S. cerevisiae) 2.50725
EMD emerin 2.45557
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.38446
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.29626
PDLIM1 PDZ and LIM domain 1 2.29603
CGRRF1 cell growth regulator with ring finger domain 1 2.16744
CLSTN3 calsyntenin 3 2.14219
GFER growth factor, augmenter of liver regeneration 2.1292
FAM174C family with sequence similarity 174 member C 2.09528
GLI1 GLI family zinc finger 1 2.07552
DPP3 dipeptidyl-peptidase 3 2.06936
NOL9 nucleolar protein 9 2.03677
GPATCH3 G patch domain containing 3 2.02902

decreased expression

Symbol Name Standardized Value
INPP1 inositol polyphosphate-1-phosphatase -5.13065
NLRP4 NLR family, pyrin domain containing 4 -4.66597
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.69368
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.64722
RAI14 retinoic acid induced 14 -2.57431
SORBS3 sorbin and SH3 domain containing 3 -2.52398
NT5DC2 5'-nucleotidase domain containing 2 -2.49177
RPA3 replication protein A3, 14kDa -2.39796
CD81 CD81 molecule -2.36221
VAMP5 vesicle-associated membrane protein 5 -2.33972
MTERF3 mitochondrial transcription termination factor 3 -2.11577
LRRC37A3 leucine rich repeat containing 37, member A3 -2.03692
STN1 STN1 subunit of CST complex -2.01238
ACTMAP actin maturation protease -2.01078