CRCGN015_MCF10A.WT.HP_24H:D07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 99.96 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 5.20429
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 4.09411
IDE insulin-degrading enzyme 3.99456
SQOR sulfide quinone oxidoreductase 3.1963
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.97776
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.80295
VGLL4 vestigial-like family member 4 2.79573
ZNF587B zinc finger protein 587B 2.61177
DENND1A DENN/MADD domain containing 1A 2.55158
ZNF551 zinc finger protein 551 2.51196
CHP2 calcineurin-like EF-hand protein 2 2.50835
ZNF134 zinc finger protein 134 2.48687
GRB7 growth factor receptor-bound protein 7 2.32998
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.31102
CRELD2 cysteine-rich with EGF-like domains 2 2.29727
MYL9 myosin, light chain 9, regulatory 2.24213
CENPE centromere protein E, 312kDa 2.23784
KRT1 keratin 1, type II 2.23407
PMCH pro-melanin-concentrating hormone 2.20681
TMEM50B transmembrane protein 50B 2.18538
RTN2 reticulon 2 2.17879
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.15733
ZNF304 zinc finger protein 304 2.14472
KLF3 Kruppel-like factor 3 (basic) 2.12974
GAR1 GAR1 ribonucleoprotein 2.0665
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.06595
SNAP29 synaptosomal-associated protein, 29kDa 2.06457
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.04249
ADSS2 adenylosuccinate synthase 2 2.04148
KRT2 keratin 2, type II 2.0366
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma 2.0339
COL3A1 collagen, type III, alpha 1 2.03309
TERT telomerase reverse transcriptase 2.02835
COL1A2 collagen, type I, alpha 2 2.0279
TESK1 testis-specific kinase 1 2.02455
SCGB2A2 secretoglobin, family 2A, member 2 2.02061
ARID5B AT rich interactive domain 5B (MRF1-like) 2.00884
ANKRD55 ankyrin repeat domain 55 2.00546
CCDC68 coiled-coil domain containing 68 2.0017

decreased expression

Symbol Name Standardized Value
CD81 CD81 molecule -4.19521
STXBP2 syntaxin binding protein 2 -3.6992
PPIC peptidylprolyl isomerase C (cyclophilin C) -3.60128
MTERF3 mitochondrial transcription termination factor 3 -3.49544
MSMO1 methylsterol monooxygenase 1 -3.32693
IFRD2 interferon-related developmental regulator 2 -3.28863
NPC2 Niemann-Pick disease, type C2 -2.39649
TKT transketolase -2.36221
CREG1 cellular repressor of E1A-stimulated genes 1 -2.36044
BASP1 brain abundant, membrane attached signal protein 1 -2.31037
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.26393
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -2.17899
RNF220 ring finger protein 220 -2.14577
SNX24 sorting nexin 24 -2.12735
HSPA1A heat shock 70kDa protein 1A -2.11359
NTM neurotrimin -2.08344
CCNO cyclin O -2.06525
LACTB2 lactamase, beta 2 -2.06335
C1QTNF3 C1q and tumor necrosis factor related protein 3 -2.04279
ARGLU1 arginine and glutamate rich 1 -2.02413
STK26 serine/threonine protein kinase 26 -2.02037
TBC1D3G TBC1 domain family member 3G -2.01831
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -2.00838
CTR9 CTR9, Paf1/RNA polymerase II complex component -2.00272