CRCGN015_MCF10A.WT.HP_24H:D08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 33.32 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MEF2C myocyte enhancer factor 2C 3.70692
AGR2 anterior gradient 2 3.55454
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.5029
SPAG4 sperm associated antigen 4 3.38983
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.25841
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 2.92237
MAMLD1 mastermind-like domain containing 1 2.74626
ACAA1 acetyl-CoA acyltransferase 1 2.64311
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.57356
MYL11 myosin light chain 11 2.53255
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.43173
MYF6 myogenic factor 6 (herculin) 2.42862
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.36736
TNNI1 troponin I type 1 (skeletal, slow) 2.35399
COMP cartilage oligomeric matrix protein 2.35133
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.34686
KLHL41 kelch-like family member 41 2.24683
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.23578
MYOT myotilin 2.21187
TPM3 tropomyosin 3 2.20811
STAP2 signal transducing adaptor family member 2 2.16943
EPHB2 EPH receptor B2 2.1193
WIF1 WNT inhibitory factor 1 2.09532
TNNC2 troponin C type 2 (fast) 2.04161
ACTA1 actin, alpha 1, skeletal muscle 2.02659
SMPX small muscle protein, X-linked 2.0257

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -5.50264
BAG3 BCL2-associated athanogene 3 -4.05506
NPDC1 neural proliferation, differentiation and control, 1 -4.04923
PCCB propionyl CoA carboxylase, beta polypeptide -3.55675
TXNDC9 thioredoxin domain containing 9 -2.24788
PCNA proliferating cell nuclear antigen -2.23954
RNF167 ring finger protein 167 -2.19205
MPC2 mitochondrial pyruvate carrier 2 -2.00965
RALGDS ral guanine nucleotide dissociation stimulator -2.00228