CRCGN015_MCF10A.WT.HP_24H:D10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description metronidazole 103.49 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 8.18071
MAP7 microtubule-associated protein 7 4.69528
HBA1 hemoglobin, alpha 1 4.49529
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.64913
TBX2 T-box 2 3.12517
RNF123 ring finger protein 123 2.78883
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.62868
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 2.4905
COL11A1 collagen, type XI, alpha 1 2.34217
FBXL12 F-box and leucine-rich repeat protein 12 2.30691
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.286
ART3 ADP-ribosyltransferase 3 2.27396
CHAMP1 chromosome alignment maintaining phosphoprotein 1 2.2535
HBB hemoglobin, beta 2.23481
MINPP1 multiple inositol-polyphosphate phosphatase 1 2.23207
PAIP2B poly(A) binding protein interacting protein 2B 2.19882
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2.19565
ACOX2 acyl-CoA oxidase 2, branched chain 2.19158
INTS11 integrator complex subunit 11 2.1466
FPGS folylpolyglutamate synthase 2.13351
WFDC1 WAP four-disulfide core domain 1 2.09288
AGR2 anterior gradient 2 2.09117
ZNF248 zinc finger protein 248 2.0767
TDO2 tryptophan 2,3-dioxygenase 2.07545
GRB7 growth factor receptor-bound protein 7 2.06592
TENT4A terminal nucleotidyltransferase 4A 2.06228
LOC128966570 alpha-amylase 1B 2.04439
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.04039
RSBN1 round spermatid basic protein 1 2.01929

decreased expression

Symbol Name Standardized Value
MSN moesin -7.39173
VAT1 vesicle amine transport 1 -5.39072
HOXA5 homeobox A5 -4.73148
CD81 CD81 molecule -4.35747
LYPLA1 lysophospholipase I -4.2076
FKBP9 FK506 binding protein 9, 63 kDa -3.58981
C2CD5 C2 calcium-dependent domain containing 5 -3.25082
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.21802
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.19359
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -3.00477
RBM34 RNA binding motif protein 34 -2.98862
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.92935
KIF14 kinesin family member 14 -2.81986
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.79573
CTNND1 catenin (cadherin-associated protein), delta 1 -2.72899
KRT14 keratin 14, type I -2.68552
ITGB1BP1 integrin beta 1 binding protein 1 -2.61392
CAPN2 calpain 2, (m/II) large subunit -2.61153
SNRPE small nuclear ribonucleoprotein polypeptide E -2.58884
BUD31 BUD31 homolog (S. cerevisiae) -2.5809
ATP5F1E ATP synthase F1 subunit epsilon -2.54996
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.4862
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.38548
KCTD12 potassium channel tetramerization domain containing 12 -2.36192
ANXA5 annexin A5 -2.31902
GPN1 GPN-loop GTPase 1 -2.31503
EIPR1 EARP complex and GARP complex interacting protein 1 -2.30327
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) -2.28535
MRPL15 mitochondrial ribosomal protein L15 -2.25232
GDF15 growth differentiation factor 15 -2.24825
SAV1 salvador family WW domain containing protein 1 -2.20386
PCYOX1 prenylcysteine oxidase 1 -2.19521
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.19474
SDCBP syndecan binding protein (syntenin) -2.18829
TOR4A torsin family 4, member A -2.18251
DEFB1 defensin, beta 1 -2.12891
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.126
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -2.12221
NSG1 neuron specific gene family member 1 -2.0618
OLA1 Obg-like ATPase 1 -2.05787
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.05176
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -2.04819
GPX4 glutathione peroxidase 4 -2.02448