CRCGN015_MCF10A.WT.HP_24H:D11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description metronidazole 34.5 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

21 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 5.53418
WIF1 WNT inhibitory factor 1 5.0
PPARG peroxisome proliferator-activated receptor gamma 3.50643
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.69362
PLSCR3 phospholipid scramblase 3 2.63021
RNASE7 ribonuclease, RNase A family, 7 2.57166
COQ8A coenzyme Q8A 2.30578
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.2619
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.17968
FBXL12 F-box and leucine-rich repeat protein 12 2.07319

decreased expression

Symbol Name Standardized Value
TUBB6 tubulin, beta 6 class V -5.45473
ADI1 acireductone dioxygenase 1 -5.20218
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.27703
MPC2 mitochondrial pyruvate carrier 2 -3.95895
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.7094
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.60258
ANXA2 annexin A2 -3.18346
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.82218
MSN moesin -2.60494
RBM15B RNA binding motif protein 15B -2.37587
TOMM70 translocase of outer mitochondrial membrane 70 -2.07221