CRCGN015_MCF10A.WT.HP_24H:D12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description metronidazole 11.5 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 5.26796
UBQLN2 ubiquilin 2 4.93627
CNPY3 canopy FGF signaling regulator 3 3.62625
KLHL9 kelch-like family member 9 3.4584
SATB1 SATB homeobox 1 2.99604
LGMN legumain 2.97768
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.96767
DENND2D DENN/MADD domain containing 2D 2.81417
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.74517
PRPF8 pre-mRNA processing factor 8 2.47003
MMP1 matrix metallopeptidase 1 2.46851
MALT1 MALT1 paracaspase 2.46252
HDAC1 histone deacetylase 1 2.42471
CGRRF1 cell growth regulator with ring finger domain 1 2.09087
ARB2A ARB2 cotranscriptional regulator A 2.06196
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.05492

decreased expression

Symbol Name Standardized Value
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.10995
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.91254
TXNDC9 thioredoxin domain containing 9 -4.82551
HSPA8 heat shock 70kDa protein 8 -4.57413
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.2654
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -2.81283
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.63898
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.62424
PDCD10 programmed cell death 10 -2.62158
UNC50 unc-50 homolog (C. elegans) -2.53178
GNRH2 gonadotropin-releasing hormone 2 -2.52902
TENT4A terminal nucleotidyltransferase 4A -2.49642
IPO13 importin 13 -2.43911
TMEM259 transmembrane protein 259 -2.43534
TUBA4A tubulin, alpha 4a -2.42075
FBXL6 F-box and leucine-rich repeat protein 6 -2.36224
EXOSC4 exosome component 4 -2.25944
THSD4 thrombospondin, type I, domain containing 4 -2.24385
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.22175
SOCS1 suppressor of cytokine signaling 1 -2.21409
ACY1 aminoacylase 1 -2.21196
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.19868
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.19418
REV1 REV1, polymerase (DNA directed) -2.18318
SGK1 serum/glucocorticoid regulated kinase 1 -2.18219
MEGF6 multiple EGF-like-domains 6 -2.15452
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.15174
LIM2 lens intrinsic membrane protein 2, 19kDa -2.13079
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.11793
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.11572
MEF2B myocyte enhancer factor 2B -2.10438
DRD4 dopamine receptor D4 -2.07709
ZFPM1 zinc finger protein, FOG family member 1 -2.07157
TMEM127 transmembrane protein 127 -2.06608
SAMD4B sterile alpha motif domain containing 4B -2.06076
ATG101 autophagy related 101 -2.05583
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B -2.05528
SPHK2 sphingosine kinase 2 -2.04738
HIC1 hypermethylated in cancer 1 -2.03512
LOC102724652 alpha-crystallin A chain -2.03217
HSF1 heat shock transcription factor 1 -2.02833
CCN6 cellular communication network factor 6 -2.02766
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -2.02544
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.00869