CRCGN015_MCF10A.WT.HP_24H:D13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1,1-trichloroethane, technical grade 98.44 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EPHB2 EPH receptor B2 4.76517
E2F2 E2F transcription factor 2 4.24209
WIF1 WNT inhibitory factor 1 3.90262
NOTCH1 notch 1 3.78592
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.16734
SH3BP1 SH3-domain binding protein 1 2.55256
PRB2 proline-rich protein BstNI subfamily 2 2.28103
MXD3 MAX dimerization protein 3 2.2398
TRIM28 tripartite motif containing 28 2.15247
FBXO34 F-box protein 34 2.14923
GLI3 GLI family zinc finger 3 2.12628
LOC102724594 splicing factor U2AF 35 kDa subunit 2.12168
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.11692
LY6G6F-LY6G6D LY6G6F-LY6G6D readthrough 2.11047
FZD8 frizzled class receptor 8 2.08306
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2.06811
PRB3 proline-rich protein BstNI subfamily 3 2.05934
WDR4 WD repeat domain 4 2.05854
HRC histidine rich calcium binding protein 2.05196
TPD52L2 tumor protein D52-like 2 2.04445
LPIN2 lipin 2 2.03737
CTRB1 chymotrypsinogen B1 2.01387
NBPF19 neuroblastoma breakpoint family, member 19 2.00742

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -9.1774
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.8234
MSMO1 methylsterol monooxygenase 1 -4.70117
CD58 CD58 molecule -4.61793
LAP3 leucine aminopeptidase 3 -4.43335
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.2798
MRPS2 mitochondrial ribosomal protein S2 -4.27632
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.13159
MSN moesin -4.04215
COPS7A COP9 signalosome subunit 7A -3.48792
RBM34 RNA binding motif protein 34 -2.93526
PFN1 profilin 1 -2.90009
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.88406
MFSD12 major facilitator superfamily domain containing 12 -2.77953
NQO2 NAD(P)H dehydrogenase, quinone 2 -2.50937
CIB1 calcium and integrin binding 1 (calmyrin) -2.25923
SQLE squalene epoxidase -2.25657
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -2.23999
MYG1 MYG1 exonuclease -2.18489
SALL1 spalt-like transcription factor 1 -2.16838
ATOX1 antioxidant 1 copper chaperone -2.09125
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.08289
HOXC10 homeobox C10 -2.0667
RND3 Rho family GTPase 3 -2.05495
MAGEA12 melanoma antigen family A12 -2.02883
ARL17B ADP-ribosylation factor-like 17B -2.01514
COQ4 coenzyme Q4 -2.01309
CBX6 chromobox homolog 6 -2.0054
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -2.00023