CRCGN015_MCF10A.WT.HP_24H:D14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1,1-trichloroethane, technical grade 32.81 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 4.97571
CNPY3 canopy FGF signaling regulator 3 4.95645
IDE insulin-degrading enzyme 4.74662
ABHD6 abhydrolase domain containing 6 4.56297
AGR2 anterior gradient 2 4.51656
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.25008
ZMIZ1 zinc finger, MIZ-type containing 1 3.95959
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3.94214
CNRIP1 cannabinoid receptor interacting protein 1 3.52262
ACAA1 acetyl-CoA acyltransferase 1 3.23665
ACLY ATP citrate lyase 3.23066
SATB1 SATB homeobox 1 2.94369
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.63645
BZW2 basic leucine zipper and W2 domains 2 2.557
QPRT quinolinate phosphoribosyltransferase 2.26208
CTSW cathepsin W 2.21668
PDIA5 protein disulfide isomerase family A, member 5 2.19556
CERK ceramide kinase 2.15768
CPAP centrosome assembly and centriole elongation protein 2.08833
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.06501
COMP cartilage oligomeric matrix protein 2.04665

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -9.32368
GDF15 growth differentiation factor 15 -5.76612
PRPF4 pre-mRNA processing factor 4 -4.73221
ACOT9 acyl-CoA thioesterase 9 -4.04114
FHL2 four and a half LIM domains 2 -3.98096
MSN moesin -3.87008
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.79796
PCCB propionyl CoA carboxylase, beta polypeptide -3.42318
VDAC1 voltage-dependent anion channel 1 -3.39363
APOO apolipoprotein O -3.14044
LOC127933115 uncharacterized LOC127933115 -2.66994
CDKN2A cyclin-dependent kinase inhibitor 2A -2.5262
CSRP1 cysteine and glycine-rich protein 1 -2.47314
SHROOM2 shroom family member 2 -2.45209
MFSD12 major facilitator superfamily domain containing 12 -2.44378
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.26632
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.24979
BSPRY B-box and SPRY domain containing -2.21034
MAGEA4 melanoma antigen family A4 -2.16383
RFPL3 ret finger protein-like 3 -2.09448
ZBTB43 zinc finger and BTB domain containing 43 -2.04949
ZNF571 zinc finger protein 571 -2.04434
BDNF brain-derived neurotrophic factor -2.02069