CRCGN015_MCF10A.WT.HP_24H:D17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-butyl chloride 34.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PNKP polynucleotide kinase 3'-phosphatase 5.27862
SSBP2 single-stranded DNA binding protein 2 4.92807
COMP cartilage oligomeric matrix protein 4.46351
KIF5C kinesin family member 5C 4.21935
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.50123
NGRN neugrin, neurite outgrowth associated 3.468
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.03105
TXNL4B thioredoxin-like 4B 2.94399
TBC1D31 TBC1 domain family, member 31 2.77371
RPL39L ribosomal protein L39-like 2.64211
EPHX2 epoxide hydrolase 2, cytoplasmic 2.63749
ACAA1 acetyl-CoA acyltransferase 1 2.629
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.60566
CRELD2 cysteine-rich with EGF-like domains 2 2.4497
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.42613
UBE2J1 ubiquitin-conjugating enzyme E2, J1 2.33286
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 2.23164
TBX2 T-box 2 2.23157
CADM1 cell adhesion molecule 1 2.21138
FRZB frizzled-related protein 2.21074
TLR1 toll-like receptor 1 2.20861
CAMTA1 calmodulin binding transcription activator 1 2.19389
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 2.16991
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.08167
PNMA8A PNMA family member 8A 2.03915
EYA1 EYA transcriptional coactivator and phosphatase 1 2.02832
CRABP1 cellular retinoic acid binding protein 1 2.02545
THSD7A thrombospondin, type I, domain containing 7A 2.00547
CHIT1 chitinase 1 (chitotriosidase) 2.00311

decreased expression

Symbol Name Standardized Value
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.76795
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.74043
GDF15 growth differentiation factor 15 -4.23835
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.00324
BASP1 brain abundant, membrane attached signal protein 1 -3.83581
MSN moesin -2.65702
CETN2 centrin, EF-hand protein, 2 -2.64285
STAT1 signal transducer and activator of transcription 1, 91kDa -2.41339
TM9SF2 transmembrane 9 superfamily member 2 -2.41045
SCYL3 SCY1-like 3 (S. cerevisiae) -2.35923
F8A2 coagulation factor VIII-associated 2 -2.27523
CD81 CD81 molecule -2.20748
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.11304
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -2.08502
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.04469
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -2.00321