CRCGN015_MCF10A.WT.HP_24H:D18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-butyl chloride 11.44 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD6 abhydrolase domain containing 6 5.10102
SNAP25 synaptosomal-associated protein, 25kDa 5.08575
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.80128
WIF1 WNT inhibitory factor 1 4.76347
SSBP2 single-stranded DNA binding protein 2 4.67053
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.50736
ANO10 anoctamin 10 4.31618
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.59882
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 3.06201
NEFM neurofilament, medium polypeptide 2.87087
UBQLN2 ubiquilin 2 2.69244
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.6196
STMN2 stathmin 2 2.5953
COMP cartilage oligomeric matrix protein 2.56933
SYN1 synapsin I 2.559
SV2B synaptic vesicle glycoprotein 2B 2.55102
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.30407
HOOK2 hook microtubule-tethering protein 2 2.28736
SYP synaptophysin 2.28167
INA internexin neuronal intermediate filament protein, alpha 2.27859
SH3GL2 SH3-domain GRB2-like 2 2.25863
PER3 period circadian clock 3 2.24898
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.22178
LBP lipopolysaccharide binding protein 2.20776
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.19705
BEX2 brain expressed X-linked 2 2.17693
SHMT1 serine hydroxymethyltransferase 1 (soluble) 2.17607
ACTL6B actin-like 6B 2.1749
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 2.13101
RNF39 ring finger protein 39 2.12468
DOCK3 dedicator of cytokinesis 3 2.12066
ADGRG2 adhesion G protein-coupled receptor G2 2.11012
FAM107A family with sequence similarity 107, member A 2.10375
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.09135
RTL8A retrotransposon Gag like 8A 2.09028
LPCAT3 lysophosphatidylcholine acyltransferase 3 2.0812
TAGLN3 transgelin 3 2.06176
NSG2 neuronal vesicle trafficking associated 2 2.04697
ZIC1 Zic family member 1 2.0408
TEX11 testis expressed 11 2.03708
SULT4A1 sulfotransferase family 4A, member 1 2.03543
SNCB synuclein, beta 2.01815
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.01357
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 2.01132
MFAP4 microfibrillar-associated protein 4 2.0078
TCEAL9 transcription elongation factor A like 9 2.0071

decreased expression

Symbol Name Standardized Value
NGRN neugrin, neurite outgrowth associated -4.96241
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.43793
VDAC1 voltage-dependent anion channel 1 -3.93127
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.97032
MSMO1 methylsterol monooxygenase 1 -2.71056
CAB39 calcium binding protein 39 -2.64
SCYL3 SCY1-like 3 (S. cerevisiae) -2.49008
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.43906
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.30627
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.20479
CHSY1 chondroitin sulfate synthase 1 -2.1977
TIMP1 TIMP metallopeptidase inhibitor 1 -2.157
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 -2.13668
LDHC lactate dehydrogenase C -2.10262
BTN2A1 butyrophilin, subfamily 2, member A1 -2.10185
WDR26 WD repeat domain 26 -2.08901