CRCGN015_MCF10A.WT.HP_24H:D19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description coumophos 97.26 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

233 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 4.67556
KCTD5 potassium channel tetramerization domain containing 5 4.59557
SNAP25 synaptosomal-associated protein, 25kDa 4.55923
RPL39L ribosomal protein L39-like 4.36133
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 4.27483
CHEK1 checkpoint kinase 1 4.00012
SNX11 sorting nexin 11 3.61184
WIF1 WNT inhibitory factor 1 3.25548
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.19296
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 3.02718
UGDH UDP-glucose 6-dehydrogenase 3.02134
MTNAP1 mitochondrial nucleoid associated protein 1 3.01722
COMP cartilage oligomeric matrix protein 2.93635
DAD1 defender against cell death 1 2.81642
MMP1 matrix metallopeptidase 1 2.76958
ORC3 origin recognition complex, subunit 3 2.7031
RIC3 RIC3 acetylcholine receptor chaperone 2.70195
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.67919
CENPQ centromere protein Q 2.65584
WDR76 WD repeat domain 76 2.6538
GDAP1 ganglioside induced differentiation associated protein 1 2.62912
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.56335
LOC128966622 putative protein N-methyltransferase FAM86B2 2.54365
PMCH pro-melanin-concentrating hormone 2.52883
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.51845
SCG3 secretogranin III 2.5156
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.49573
ACAA1 acetyl-CoA acyltransferase 1 2.49384
SYP synaptophysin 2.47311
ARHGAP11A Rho GTPase activating protein 11A 2.45959
LOC102724560 cystathionine beta-synthase 2.45624
FOXO3 forkhead box O3 2.45191
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.4482
L2HGDH L-2-hydroxyglutarate dehydrogenase 2.44103
NVL nuclear VCP-like 2.4222
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 2.4203
BPHL biphenyl hydrolase-like (serine hydrolase) 2.40809
ACTL6A actin-like 6A 2.40679
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.3936
CYBC1 cytochrome b-245 chaperone 1 2.37014
FNDC3B fibronectin type III domain containing 3B 2.35657
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 2.35504
PCSK1 proprotein convertase subtilisin/kexin type 1 2.35114
IL33R interleukin 33 receptor 2.34081
IL26 interleukin 26 2.31915
NAV2 neuron navigator 2 2.31644
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.31098
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 2.30986
CCL1 chemokine (C-C motif) ligand 1 2.30518
SBSPON somatomedin B and thrombospondin, type 1 domain containing 2.29132
RNF13 ring finger protein 13 2.291
RGS7 regulator of G-protein signaling 7 2.29018
FAM117A family with sequence similarity 117, member A 2.28135
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.27414
PRTN3 proteinase 3 2.27067
MTERF4 mitochondrial transcription termination factor 4 2.26948
EFCAB6 EF-hand calcium binding domain 6 2.26629
VSIG2 V-set and immunoglobulin domain containing 2 2.26336
TEDC2 tubulin epsilon and delta complex 2 2.2575
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.24975
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.24938
GRB7 growth factor receptor-bound protein 7 2.24064
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.23724
ADAM23 ADAM metallopeptidase domain 23 2.23634
ETAA1 Ewing tumor-associated antigen 1 2.23188
AOC2 amine oxidase, copper containing 2 (retina-specific) 2.23018
IL9 interleukin 9 2.22746
NGRN neugrin, neurite outgrowth associated 2.22635
KNTC1 kinetochore associated 1 2.22034
MYEF2 myelin expression factor 2 2.21823
DENND4A DENN/MADD domain containing 4A 2.20205
INHBE inhibin, beta E 2.19929
RPUSD2 RNA pseudouridylate synthase domain containing 2 2.19218
TAC1 tachykinin, precursor 1 2.19202
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 2.19036
UBE2J1 ubiquitin-conjugating enzyme E2, J1 2.18795
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.17892
LGI2 leucine-rich repeat LGI family, member 2 2.17504
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.17124
SEZ6L2 seizure related 6 homolog (mouse)-like 2 2.17011
CCN5 cellular communication network factor 5 2.16647
ARR3 arrestin 3, retinal (X-arrestin) 2.16256
DKK4 dickkopf WNT signaling pathway inhibitor 4 2.16026
BFSP2 beaded filament structural protein 2, phakinin 2.15932
PRDM13 PR domain containing 13 2.15897
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 2.1573
KIF18A kinesin family member 18A 2.15127
CENPX centromere protein X 2.14878
TUBGCP5 tubulin, gamma complex associated protein 5 2.14007
FANCG Fanconi anemia, complementation group G 2.13818
NSG2 neuronal vesicle trafficking associated 2 2.13278
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.13114
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 2.12843
SIRT6 sirtuin 6 2.1171
EIF5A2 eukaryotic translation initiation factor 5A2 2.11705
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.11584
H2BC3 H2B clustered histone 3 2.11431
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.11146
BYSL bystin-like 2.10772
NTF3 neurotrophin 3 2.10692
ZNF227 zinc finger protein 227 2.09675
PTPRN protein tyrosine phosphatase, receptor type, N 2.09619
RAD51 RAD51 recombinase 2.09542
PARPBP PARP1 binding protein 2.09141
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.08418
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 2.08285
HOXA7 homeobox A7 2.07759
CLDN14 claudin 14 2.07583
THAP9 THAP domain containing 9 2.07497
RTN2 reticulon 2 2.07203
DMAP1 DNA methyltransferase 1 associated protein 1 2.06326
MANEA mannosidase, endo-alpha 2.06261
SCG2 secretogranin II 2.06245
DPYSL3 dihydropyrimidinase-like 3 2.05892
SHOX2 short stature homeobox 2 2.05836
H2BC15 H2B clustered histone 15 2.05658
LIN28A lin-28 homolog A (C. elegans) 2.05585
GCAT glycine C-acetyltransferase 2.05423
DSCC1 DNA replication and sister chromatid cohesion 1 2.04209
METTL16 methyltransferase like 16 2.0392
SLC35G2 solute carrier family 35, member G2 2.03657
CEP97 centrosomal protein 97kDa 2.03335
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.03066
BMP6 bone morphogenetic protein 6 2.02972
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 2.02897
CEP152 centrosomal protein 152kDa 2.02385
HAUS6 HAUS augmin-like complex, subunit 6 2.02138
RPAIN RPA interacting protein 2.01985
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 2.01286
CD160 CD160 molecule 2.01136
PAX6 paired box 6 2.01017
PVALB parvalbumin 2.0094
SCAMP5 secretory carrier membrane protein 5 2.00891
CXADR coxsackie virus and adenovirus receptor 2.00707
OIP5 Opa interacting protein 5 2.00579
TMEM156 transmembrane protein 156 2.00554
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 2.0045

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -6.40978
COG7 component of oligomeric golgi complex 7 -5.1301
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.02221
GDF15 growth differentiation factor 15 -4.89597
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.82755
BID BH3 interacting domain death agonist -4.80261
PYGL phosphorylase, glycogen, liver -4.49826
CCNB1 cyclin B1 -4.30087
ALDOC aldolase C, fructose-bisphosphate -4.1912
CTNND1 catenin (cadherin-associated protein), delta 1 -3.63152
NISCH nischarin -3.54903
CD81 CD81 molecule -3.48763
TIMP1 TIMP metallopeptidase inhibitor 1 -3.39997
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.17497
RGS2 regulator of G-protein signaling 2 -3.15682
R3HDM2 R3H domain containing 2 -3.04846
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -3.04095
SH3D19 SH3 domain containing 19 -3.01893
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.97764
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 -2.88707
MTERF3 mitochondrial transcription termination factor 3 -2.74978
DSE dermatan sulfate epimerase -2.74639
HOMER1 homer scaffolding protein 1 -2.69047
ZFYVE16 zinc finger, FYVE domain containing 16 -2.67642
INSIG1 insulin induced gene 1 -2.62368
ADRB2 adrenoceptor beta 2, surface -2.55058
ZDHHC7 zinc finger, DHHC-type containing 7 -2.54662
DENND5A DENN/MADD domain containing 5A -2.519
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.51475
FOXJ3 forkhead box J3 -2.50034
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.49575
FUCA1 fucosidase, alpha-L- 1, tissue -2.49296
TEX264 testis expressed 264 -2.48717
TM9SF2 transmembrane 9 superfamily member 2 -2.4683
DTX4 deltex 4, E3 ubiquitin ligase -2.44961
IRS2 insulin receptor substrate 2 -2.44934
ANXA2 annexin A2 -2.43689
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.43164
BBOF1 basal body orientation factor 1 -2.3927
RAB5B RAB5B, member RAS oncogene family -2.38879
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.38563
TMEM50A transmembrane protein 50A -2.36138
TSPAN14 tetraspanin 14 -2.3485
RPL26L1 ribosomal protein L26-like 1 -2.34615
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.33297
OXCT1 3-oxoacid CoA transferase 1 -2.32363
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.31526
PCDHB16 protocadherin beta 16 -2.3143
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.30511
RBMX RNA binding motif protein, X-linked -2.3017
ZNF629 zinc finger protein 629 -2.28954
SSRP1 structure specific recognition protein 1 -2.26572
DHCR7 7-dehydrocholesterol reductase -2.26281
LZTFL1 leucine zipper transcription factor-like 1 -2.2569
NYNRIN NYN domain and retroviral integrase containing -2.25181
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.23807
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -2.23477
SGPL1 sphingosine-1-phosphate lyase 1 -2.23054
LDHD lactate dehydrogenase D -2.21616
CEPT1 choline/ethanolamine phosphotransferase 1 -2.21439
LIPT1 lipoyltransferase 1 -2.20087
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.19448
TSPAN31 tetraspanin 31 -2.19288
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.17713
ARID4B AT rich interactive domain 4B (RBP1-like) -2.16359
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.16044
UBFD1 ubiquitin family domain containing 1 -2.15884
HCK HCK proto-oncogene, Src family tyrosine kinase -2.1567
CDKN3 cyclin-dependent kinase inhibitor 3 -2.15164
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -2.14936
CHD3 chromodomain helicase DNA binding protein 3 -2.14628
CLK4 CDC-like kinase 4 -2.13987
WDR37 WD repeat domain 37 -2.13282
ATG9A autophagy related 9A -2.13268
BAZ2B bromodomain adjacent to zinc finger domain, 2B -2.12116
CBR3 carbonyl reductase 3 -2.11594
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.1151
RETREG3 reticulophagy regulator family member 3 -2.1093
NTM neurotrimin -2.0907
PRCP prolylcarboxypeptidase (angiotensinase C) -2.08607
OXSR1 oxidative stress responsive 1 -2.08017
UNC119B unc-119 homolog B (C. elegans) -2.07285
FOXO4 forkhead box O4 -2.0682
ERCC5 excision repair cross-complementation group 5 -2.05394
NPC2 Niemann-Pick disease, type C2 -2.04833
NUP133 nucleoporin 133kDa -2.04765
WDR6 WD repeat domain 6 -2.04308
CCNG1 cyclin G1 -2.03995
CLEC7A C-type lectin domain family 7, member A -2.03432
FBXW4 F-box and WD repeat domain containing 4 -2.03127
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.02092
S100P S100 calcium binding protein P -2.02037
EIF3I eukaryotic translation initiation factor 3, subunit I -2.01924
ADGRE2 adhesion G protein-coupled receptor E2 -2.01614
PTDSS1 phosphatidylserine synthase 1 -2.01572
CHPT1 choline phosphotransferase 1 -2.01334