CRCGN015_MCF10A.WT.HP_24H:D24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-n'-[3-(trifluoromethyl)phenyl]urea 10.73 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

211 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:D24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 5.17108
INTS3 integrator complex subunit 3 5.15872
CCP110 centriolar coiled coil protein 110kDa 4.92024
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.6027
CNPY3 canopy FGF signaling regulator 3 4.36319
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.28875
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.71565
WDR7 WD repeat domain 7 3.7095
PMM2 phosphomannomutase 2 3.29447
COMP cartilage oligomeric matrix protein 3.18379
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.00454
IFT57 intraflagellar transport 57 2.95213
MNS1 meiosis-specific nuclear structural 1 2.94032
EFHC1 EF-hand domain (C-terminal) containing 1 2.92931
FCHO1 FCH domain only 1 2.92885
CIAO3 cytosolic iron-sulfur assembly component 3 2.91385
TLR5 toll-like receptor 5 2.83849
FSD1 fibronectin type III and SPRY domain containing 1 2.82659
CDR2L cerebellar degeneration-related protein 2-like 2.73713
UGDH UDP-glucose 6-dehydrogenase 2.68242
ILF2 interleukin enhancer binding factor 2 2.62807
MTMR14 myotubularin related protein 14 2.60918
RTL10 retrotransposon Gag like 10 2.60324
TRIM13 tripartite motif containing 13 2.57488
ACAA1 acetyl-CoA acyltransferase 1 2.55858
RAG1 recombination activating gene 1 2.55818
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.53593
TP73 tumor protein p73 2.53413
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.532
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.50894
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 2.50512
NMU neuromedin U 2.50149
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3 2.49844
CEND1 cell cycle exit and neuronal differentiation 1 2.4957
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.46722
RNFT1-DT RNFT1 divergent transcript 2.46571
SESN1 sestrin 1 2.45533
DNM1 dynamin 1 2.45314
PRR7 proline rich 7 (synaptic) 2.45
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.43586
IL7 interleukin 7 2.41923
ZNF74 zinc finger protein 74 2.40959
ACVRL1 activin A receptor type II-like 1 2.40835
CLIP2 CAP-GLY domain containing linker protein 2 2.40534
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.40025
C5 complement component 5 2.38693
FIG4 FIG4 phosphoinositide 5-phosphatase 2.38604
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.3849
TPD52L2 tumor protein D52-like 2 2.36795
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.36561
CPTP ceramide-1-phosphate transfer protein 2.34334
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.33453
TCL1B T-cell leukemia/lymphoma 1B 2.33373
RIPOR1 RHO family interacting cell polarization regulator 1 2.31325
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.30774
AEBP1 AE binding protein 1 2.30684
CEP131 centrosomal protein 131kDa 2.30652
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 2.30093
NOTCH4 notch 4 2.2949
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.28322
GFPT2 glutamine-fructose-6-phosphate transaminase 2 2.27518
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 2.25007
RTN1 reticulon 1 2.24983
DTX2 deltex 2, E3 ubiquitin ligase 2.24554
ATP11B ATPase, class VI, type 11B 2.24252
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.23875
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.23024
FAM193B family with sequence similarity 193, member B 2.2271
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 2.21724
MARK4 MAP/microtubule affinity-regulating kinase 4 2.2116
ZDHHC13 zinc finger, DHHC-type containing 13 2.20673
RNF31 ring finger protein 31 2.2051
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 2.19852
BCR breakpoint cluster region 2.18941
DNAH6 dynein, axonemal, heavy chain 6 2.18622
APH1A APH1A gamma secretase subunit 2.18429
ATG7 autophagy related 7 2.18281
ZC3H3 zinc finger CCCH-type containing 3 2.17101
LOC122526780 uncharacterized LOC122526780 2.17074
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 2.16349
ZFP37 ZFP37 zinc finger protein 2.16103
RAB15 RAB15, member RAS oncogene family 2.15618
ADGRA2 adhesion G protein-coupled receptor A2 2.15372
PRAMEF12 PRAME family member 12 2.15339
DGCR2 DiGeorge syndrome critical region gene 2 2.15279
MAP3K11 mitogen-activated protein kinase kinase kinase 11 2.15021
CLXN calaxin 2.14187
NAGA N-acetylgalactosaminidase, alpha- 2.14153
DCAF10 DDB1 and CUL4 associated factor 10 2.14123
DLK2 delta-like 2 homolog (Drosophila) 2.14073
FAM234B family with sequence similarity 234 member B 2.14046
HEBP2 heme binding protein 2 2.13961
TBC1D31 TBC1 domain family, member 31 2.13866
IL13RA1 interleukin 13 receptor, alpha 1 2.1314
CD1B CD1b molecule 2.13115
TTC26 tetratricopeptide repeat domain 26 2.12838
DIPK1A divergent protein kinase domain 1A 2.11959
PRMT7 protein arginine methyltransferase 7 2.11626
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.11559
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.11225
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 2.11225
MCPH1 microcephalin 1 2.10876
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.10754
BPHL biphenyl hydrolase-like (serine hydrolase) 2.10541
MMP2 matrix metallopeptidase 2 2.10515
ECSIT ECSIT signalling integrator 2.10311
RTN2 reticulon 2 2.10186
TBC1D10B TBC1 domain family, member 10B 2.08284
SLC4A3 solute carrier family 4 (anion exchanger), member 3 2.0805
MARCHF2 membrane associated ring-CH-type finger 2 2.07978
TCTN1 tectonic family member 1 2.0744
SPATA7 spermatogenesis associated 7 2.0731
ARID5A AT rich interactive domain 5A (MRF1-like) 2.07088
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.06852
PMM1 phosphomannomutase 1 2.06592
IPO4 importin 4 2.06396
MON1B MON1 secretory trafficking family member B 2.05976
NIT1 nitrilase 1 2.05945
GPR162 G protein-coupled receptor 162 2.05612
DOK7 docking protein 7 2.05385
STRN4 striatin, calmodulin binding protein 4 2.05326
BCL7C B-cell CLL/lymphoma 7C 2.05018
ELOVL4 ELOVL fatty acid elongase 4 2.04904
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 2.04832
DZANK1 double zinc ribbon and ankyrin repeat domains 1 2.04812
KREMEN2 kringle containing transmembrane protein 2 2.03677
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.03438
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.02734
FOXK2 forkhead box K2 2.02337
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.01884
FECH ferrochelatase 2.01696
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.01512
CUL7 cullin 7 2.01267
ZNF532 zinc finger protein 532 2.01115
NALF1 NALCN channel auxiliary factor 1 2.01072
CTNNBIP1 catenin, beta interacting protein 1 2.00408
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 2.00297
PSENEN presenilin enhancer gamma secretase subunit 2.00109

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -5.57896
PGAM4 phosphoglycerate mutase family member 4 -5.00862
MSN moesin -4.98624
TRAPPC3 trafficking protein particle complex 3 -4.55604
HMG20B high mobility group 20B -4.27405
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.984
BASP1 brain abundant, membrane attached signal protein 1 -3.6109
GDF15 growth differentiation factor 15 -3.59149
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.50383
OXA1L oxidase (cytochrome c) assembly 1-like -3.29343
MTA1 metastasis associated 1 -3.17272
NGRN neugrin, neurite outgrowth associated -2.99514
TSPAN3 tetraspanin 3 -2.98722
GLOD4 glyoxalase domain containing 4 -2.8516
LDHA lactate dehydrogenase A -2.81489
LOC102724594 splicing factor U2AF 35 kDa subunit -2.80226
FEM1C fem-1 homolog c (C. elegans) -2.63874
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -2.60735
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -2.59556
FAM216A family with sequence similarity 216, member A -2.59488
MRPS30 mitochondrial ribosomal protein S30 -2.59301
RPN2 ribophorin II -2.55546
RALGDS ral guanine nucleotide dissociation stimulator -2.53181
WAPL WAPL cohesin release factor -2.50061
CREG1 cellular repressor of E1A-stimulated genes 1 -2.47301
PDIA3 protein disulfide isomerase family A, member 3 -2.42211
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -2.39163
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -2.38444
EBNA1BP2 EBNA1 binding protein 2 -2.38316
SNIP1 Smad nuclear interacting protein 1 -2.3569
STXBP2 syntaxin binding protein 2 -2.35267
S100PBP S100P binding protein -2.30341
CD81 CD81 molecule -2.29489
MAPK6 mitogen-activated protein kinase 6 -2.29456
TNNC1 troponin C type 1 (slow) -2.28231
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.24683
GSTO1 glutathione S-transferase omega 1 -2.22953
SAR1A secretion associated, Ras related GTPase 1A -2.22186
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -2.21279
MSL1 male-specific lethal 1 homolog (Drosophila) -2.19683
TMEM11 transmembrane protein 11 -2.19554
GHITM growth hormone inducible transmembrane protein -2.19425
PEF1 penta-EF-hand domain containing 1 -2.19177
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.18987
FOSL1 FOS-like antigen 1 -2.1852
BST2 bone marrow stromal cell antigen 2 -2.18376
CBX3 chromobox homolog 3 -2.16815
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -2.14631
LYRM9 LYR motif containing 9 -2.13247
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -2.12966
MOAP1 modulator of apoptosis 1 -2.12923
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.12078
KRT18 keratin 18, type I -2.11997
SH3D19 SH3 domain containing 19 -2.10906
HEXB hexosaminidase B (beta polypeptide) -2.10334
IFI27 interferon, alpha-inducible protein 27 -2.10192
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.09932
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -2.07835
RLF rearranged L-myc fusion -2.07178
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.07129
MEAF6 MYST/Esa1-associated factor 6 -2.06996
ACOT9 acyl-CoA thioesterase 9 -2.06761
TERF2IP telomeric repeat binding factor 2, interacting protein -2.05866
THOC2 THO complex 2 -2.0531
HNRNPK heterogeneous nuclear ribonucleoprotein K -2.04745
ECD ecdysoneless homolog (Drosophila) -2.04664
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.04183
TNPO1 transportin 1 -2.03663
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -2.03423
PRDX1 peroxiredoxin 1 -2.0338
PKM pyruvate kinase, muscle -2.01851
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 -2.01365
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.00687