CRCGN015_MCF10A.WT.HP_24H:E01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tin (ii) chloride 99.96 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:E01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 4.00053
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.38749
MED28 mediator complex subunit 28 2.56027
TBX2 T-box 2 2.53961
CCL2 chemokine (C-C motif) ligand 2 2.37003
ADGRE5 adhesion G protein-coupled receptor E5 2.32466
DCTN3 dynactin 3 (p22) 2.30768
BLMH bleomycin hydrolase 2.26289
LMO4 LIM domain only 4 2.17732
STOML2 stomatin (EPB72)-like 2 2.09455
DCXR dicarbonyl/L-xylulose reductase 2.0724
DNMBP dynamin binding protein 2.06494

decreased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic -7.50097
MSMO1 methylsterol monooxygenase 1 -5.43934
NPDC1 neural proliferation, differentiation and control, 1 -4.8772
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.87018
HMG20B high mobility group 20B -4.85455
TXNDC9 thioredoxin domain containing 9 -4.54521
COG7 component of oligomeric golgi complex 7 -3.70844
TCTA T-cell leukemia translocation altered -3.50159
ACOX2 acyl-CoA oxidase 2, branched chain -2.96871
FBXO7 F-box protein 7 -2.63328
EIF5B eukaryotic translation initiation factor 5B -2.57553
GMPPB GDP-mannose pyrophosphorylase B -2.53641
RHOB ras homolog family member B -2.51739
COX5B cytochrome c oxidase subunit Vb -2.49884
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -2.42478
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.4232
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -2.34007
GGCT gamma-glutamylcyclotransferase -2.30453
SKAP2 src kinase associated phosphoprotein 2 -2.2099
HPR haptoglobin-related protein -2.19089
UFM1 ubiquitin-fold modifier 1 -2.18947
LIPT1 lipoyltransferase 1 -2.18076
ND5 NADH dehydrogenase subunit 5 -2.17203
RANBP2 RAN binding protein 2 -2.16409
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.16037
CD81 CD81 molecule -2.15942
ACY1 aminoacylase 1 -2.13647
CBX3 chromobox homolog 3 -2.13092
LZTFL1 leucine zipper transcription factor-like 1 -2.12543
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -2.10544
SPON1 spondin 1, extracellular matrix protein -2.10254
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -2.04524
PTPRK protein tyrosine phosphatase, receptor type, K -2.04125
ACSM5 acyl-CoA synthetase medium-chain family member 5 -2.03877
SATB2 SATB homeobox 2 -2.02316