CRCGN015_MCF10A.WT.HP_24H:E02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tin (ii) chloride 33.32 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

184 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:E02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 5.73714
PPARG peroxisome proliferator-activated receptor gamma 5.16397
SNAP25 synaptosomal-associated protein, 25kDa 4.49188
SSBP2 single-stranded DNA binding protein 2 4.22286
MAP7 microtubule-associated protein 7 4.2127
STK10 serine/threonine kinase 10 3.99997
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.81005
DENND2D DENN/MADD domain containing 2D 3.63896
COMP cartilage oligomeric matrix protein 3.57887
NOSIP nitric oxide synthase interacting protein 3.50841
SPTBN4 spectrin, beta, non-erythrocytic 4 3.32343
LYN LYN proto-oncogene, Src family tyrosine kinase 3.2788
ACAA1 acetyl-CoA acyltransferase 1 3.15945
COL16A1 collagen, type XVI, alpha 1 3.07436
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 3.02578
SIX1 SIX homeobox 1 2.95742
EDC4 enhancer of mRNA decapping 4 2.93639
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.92824
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.92051
IGHMBP2 immunoglobulin mu binding protein 2 2.84421
TSC22D4 TSC22 domain family, member 4 2.7545
TBC1D12 TBC1 domain family, member 12 2.71328
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 2.66869
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.64218
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.63753
ZNF432 zinc finger protein 432 2.61943
SIRT2 sirtuin 2 2.61359
EFHD2 EF-hand domain family, member D2 2.60819
RIPOR1 RHO family interacting cell polarization regulator 1 2.57135
INF2 inverted formin, FH2 and WH2 domain containing 2.55092
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.52252
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.52111
RHOC ras homolog family member C 2.50041
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.50017
NT5C 5', 3'-nucleotidase, cytosolic 2.49369
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.48504
CCT7 chaperonin containing TCP1, subunit 7 (eta) 2.48324
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 2.47563
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.4747
CORO7-PAM16 CORO7-PAM16 readthrough 2.46384
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.45828
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.44457
ZNF574 zinc finger protein 574 2.43119
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.42977
HMX1 H6 family homeobox 1 2.40252
ARID5B AT rich interactive domain 5B (MRF1-like) 2.39317
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.33629
INSL4 insulin-like 4 (placenta) 2.33382
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.33305
TOB2 transducer of ERBB2, 2 2.33127
PIH1D1 PIH1 domain containing 1 2.29733
CD37 CD37 molecule 2.29646
OSR2 odd-skipped related transciption factor 2 2.29612
ARMCX5 armadillo repeat containing, X-linked 5 2.28245
TSPAN6 tetraspanin 6 2.27203
ANKRD28 ankyrin repeat domain 28 2.27095
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.26311
MISP mitotic spindle positioning 2.26226
THAP12 THAP domain containing 12 2.25426
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.25132
AUP1 ancient ubiquitous protein 1 2.23924
ATAD3A ATPase family, AAA domain containing 3A 2.23696
SSNA1 Sjogren syndrome nuclear autoantigen 1 2.22452
SOCS6 suppressor of cytokine signaling 6 2.22192
CRTC3 CREB regulated transcription coactivator 3 2.21156
SH3BP1 SH3-domain binding protein 1 2.20953
BCAS1 breast carcinoma amplified sequence 1 2.2063
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.19787
CTSF cathepsin F 2.19592
ERCC2 excision repair cross-complementation group 2 2.19064
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2.18844
S100P S100 calcium binding protein P 2.18007
JAK1 Janus kinase 1 2.17945
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.16667
MAP6D1 MAP6 domain containing 1 2.15808
IL2RG interleukin 2 receptor, gamma 2.15059
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 2.14408
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 2.1406
PARP12 poly (ADP-ribose) polymerase family, member 12 2.13401
PDIA5 protein disulfide isomerase family A, member 5 2.13277
STRN4 striatin, calmodulin binding protein 4 2.13159
PRMT7 protein arginine methyltransferase 7 2.12914
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.12524
TRAF3 TNF receptor-associated factor 3 2.114
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 2.11173
FGL1 fibrinogen-like 1 2.11113
PDE4B phosphodiesterase 4B, cAMP-specific 2.10759
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 2.0984
HDAC7 histone deacetylase 7 2.09788
CALB1 calbindin 1, 28kDa 2.09702
PRMT1 protein arginine methyltransferase 1 2.08641
DOLK dolichol kinase 2.0712
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.07079
CCDC71 coiled-coil domain containing 71 2.06979
FKBP6 FK506 binding protein 6, 36kDa 2.05829
GP2 glycoprotein 2 (zymogen granule membrane) 2.05322
ZNF222 zinc finger protein 222 2.05153
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.04005
TRIM28 tripartite motif containing 28 2.02063
LMNA lamin A/C 2.01788
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 2.01122
SYT1 synaptotagmin I 2.00773
SPAG1 sperm associated antigen 1 2.00495
RABEPK Rab9 effector protein with kelch motifs 2.00182

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -6.15885
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.13628
MAPK13 mitogen-activated protein kinase 13 -5.08741
PLK1 polo-like kinase 1 -4.66184
NT5DC2 5'-nucleotidase domain containing 2 -4.25358
PPIC peptidylprolyl isomerase C (cyclophilin C) -4.21166
TES testin LIM domain protein -3.8983
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.8478
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.59614
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.56051
RPA3 replication protein A3, 14kDa -3.21649
OSTM1 osteopetrosis associated transmembrane protein 1 -3.17481
SGK1 serum/glucocorticoid regulated kinase 1 -3.16898
LCMT1 leucine carboxyl methyltransferase 1 -3.02271
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.91215
NMRK2 nicotinamide riboside kinase 2 -2.82776
HTRA1 HtrA serine peptidase 1 -2.82207
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.69616
RBM34 RNA binding motif protein 34 -2.64203
ADSS2 adenylosuccinate synthase 2 -2.61933
PDZK1IP1 PDZK1 interacting protein 1 -2.59843
PRCP prolylcarboxypeptidase (angiotensinase C) -2.56381
TMPRSS11D transmembrane protease, serine 11D -2.55424
TKT transketolase -2.48867
RAB38 RAB38, member RAS oncogene family -2.44116
EXOSC4 exosome component 4 -2.43116
PARN poly(A)-specific ribonuclease -2.42599
SCFD1 sec1 family domain containing 1 -2.41553
FKBPL FK506 binding protein like -2.3988
PITX2 paired-like homeodomain 2 -2.3694
HILPDA hypoxia inducible lipid droplet-associated -2.33119
NRN1 neuritin 1 -2.32555
ANKMY2 ankyrin repeat and MYND domain containing 2 -2.32271
PIGP phosphatidylinositol glycan anchor biosynthesis, class P -2.31166
GPX3 glutathione peroxidase 3 -2.29312
EPPK1 epiplakin 1 -2.28359
ECHDC3 enoyl CoA hydratase domain containing 3 -2.28195
GID8 GID complex subunit 8 -2.27327
MDH1 malate dehydrogenase 1, NAD (soluble) -2.2687
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.26664
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.26156
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) -2.22929
HPS5 Hermansky-Pudlak syndrome 5 -2.22565
TMEM132A transmembrane protein 132A -2.22143
CRYAB crystallin, alpha B -2.21583
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -2.2132
USO1 USO1 vesicle transport factor -2.20779
LIN28A lin-28 homolog A (C. elegans) -2.20719
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.20408
COX7C cytochrome c oxidase subunit VIIc -2.18895
TTC1 tetratricopeptide repeat domain 1 -2.18854
RHCG Rh family, C glycoprotein -2.18846
STX8 syntaxin 8 -2.17334
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.16052
NME3 NME/NM23 nucleoside diphosphate kinase 3 -2.15548
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.1457
LOC124906748 beta-defensin 4A -2.14492
KRT76 keratin 76, type II -2.14374
RGS5 regulator of G-protein signaling 5 -2.13732
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.13094
STEAP1B STEAP family member 1B -2.12285
NDN necdin, melanoma antigen (MAGE) family member -2.11282
LRRC61 leucine rich repeat containing 61 -2.10401
MED20 mediator complex subunit 20 -2.10219
PFN2 profilin 2 -2.09256
HAND1 heart and neural crest derivatives expressed 1 -2.08994
CRIPTO3 cripto, EGF-CFC family member 3 -2.0726
GSDME gasdermin E -2.07169
MOSPD1 motile sperm domain containing 1 -2.06841
CD1D CD1d molecule -2.05665
ALG11 ALG11, alpha-1,2-mannosyltransferase -2.05197
NES nestin -2.05094
PALB2 partner and localizer of BRCA2 -2.04485
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 -2.04299
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.03553
MMUT methylmalonyl-CoA mutase -2.01634
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.01619
KLK12 kallikrein-related peptidase 12 -2.01197
TGDS TDP-glucose 4,6-dehydratase -2.00208
RNF187 ring finger protein 187 -2.00111