CRCGN015_MCF10A.WT.HP_24H:E03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tin (ii) chloride 11.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:E03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHL9 kelch-like family member 9 4.49809
MAP7 microtubule-associated protein 7 4.46001
CIAO3 cytosolic iron-sulfur assembly component 3 3.79194
SPAG4 sperm associated antigen 4 3.69791
NOTCH1 notch 1 3.36779
H2BC21 H2B clustered histone 21 3.09716
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.95754
PRKX protein kinase, X-linked 2.7124
CORO1A coronin, actin binding protein, 1A 2.67044
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.66475
WASHC4 WASH complex subunit 4 2.59542
RAB21 RAB21, member RAS oncogene family 2.33536
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.24724
SOCS2 suppressor of cytokine signaling 2 2.18551
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 2.15672
BLNK B-cell linker 2.15178
DIPK1A divergent protein kinase domain 1A 2.12644
CD79B CD79b molecule, immunoglobulin-associated beta 2.10939
COMP cartilage oligomeric matrix protein 2.07405

decreased expression

Symbol Name Standardized Value
ACOT9 acyl-CoA thioesterase 9 -5.38355
CYCS cytochrome c, somatic -5.3183
TRAPPC3 trafficking protein particle complex 3 -4.58636
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.96349
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.75968
CAB39 calcium binding protein 39 -3.64037
MRPS15 mitochondrial ribosomal protein S15 -2.80373
MAP7D1 MAP7 domain containing 1 -2.69716
APOO apolipoprotein O -2.43106
GSDME gasdermin E -2.39367
RFK riboflavin kinase -2.38522
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.25394
RALGDS ral guanine nucleotide dissociation stimulator -2.2418
IL2RG interleukin 2 receptor, gamma -2.21883
UTP11 UTP11 small subunit processome component -2.18431
SNX24 sorting nexin 24 -2.1839
CORO2B coronin, actin binding protein, 2B -2.18351
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -2.17242
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.16866
PINLYP phospholipase A2 inhibitor and LY6/PLAUR domain containing -2.1002
PHC2 polyhomeotic homolog 2 (Drosophila) -2.09666
STEAP1 six transmembrane epithelial antigen of the prostate 1 -2.0937
COX5A cytochrome c oxidase subunit Va -2.04553
SERF1A small EDRK-rich factor 1A (telomeric) -2.04295
PSRC1 proline/serine-rich coiled-coil 1 -2.02144
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -2.00202