CRCGN015_MCF10A.WT.HP_24H:E08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methenamine 33.49 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

23 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:E08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADAM10 ADAM metallopeptidase domain 10 3.75997
OXSR1 oxidative stress responsive 1 3.19154
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.76017
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.68743
VGLL4 vestigial-like family member 4 2.67667
FGFR4 fibroblast growth factor receptor 4 2.57236
KIF5C kinesin family member 5C 2.48258
KDM5D lysine (K)-specific demethylase 5D 2.20256
GRB10 growth factor receptor-bound protein 10 2.16694
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.09405
COMP cartilage oligomeric matrix protein 2.08509

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -4.08046
HMG20B high mobility group 20B -3.9175
BAG3 BCL2-associated athanogene 3 -3.48095
GDF15 growth differentiation factor 15 -3.34228
FBXO21 F-box protein 21 -2.30985
QPCT glutaminyl-peptide cyclotransferase -2.28634
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.26999
ARID4B AT rich interactive domain 4B (RBP1-like) -2.21746
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.1403
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) -2.08225
SMC1A structural maintenance of chromosomes 1A -2.06778
KDM5C lysine (K)-specific demethylase 5C -2.01538