CRCGN015_MCF10A.WT.HP_24H:E09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methenamine 11.16 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:E09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD6 abhydrolase domain containing 6 3.83388
NOTCH1 notch 1 3.81904
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.78373
MAST2 microtubule associated serine/threonine kinase 2 3.7308
CHEK1 checkpoint kinase 1 3.35878
WIF1 WNT inhibitory factor 1 2.98145
SESN1 sestrin 1 2.8406
CNPY3 canopy FGF signaling regulator 3 2.72946
MMP1 matrix metallopeptidase 1 2.21043
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.16012
C1QA complement component 1, q subcomponent, A chain 2.11347
SNX11 sorting nexin 11 2.08501
FKBP5 FK506 binding protein 5 2.06299
C1QB complement component 1, q subcomponent, B chain 2.06146
COMP cartilage oligomeric matrix protein 2.02564

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -8.34989
TRAPPC3 trafficking protein particle complex 3 -4.05019
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.04127
CD44 CD44 molecule (Indian blood group) -3.89642
PPIC peptidylprolyl isomerase C (cyclophilin C) -3.5295
TKT transketolase -2.94788
HEATR1 HEAT repeat containing 1 -2.90814
PMM2 phosphomannomutase 2 -2.85453
EEF2 eukaryotic translation elongation factor 2 -2.59493
TIMP1 TIMP metallopeptidase inhibitor 1 -2.56353
MRPS15 mitochondrial ribosomal protein S15 -2.47111
ANXA2 annexin A2 -2.39207
KIAA0319L KIAA0319-like -2.25613
MFSD12 major facilitator superfamily domain containing 12 -2.12995
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 -2.12848
BSG basigin (Ok blood group) -2.09146
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.07245
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.05325
GPX4 glutathione peroxidase 4 -2.00342