CRCGN015_MCF10A.WT.HP_24H:E10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-methyl?aniline) 100.97 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:E10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 6.47726
ANO10 anoctamin 10 4.42929
MEF2C myocyte enhancer factor 2C 3.72318
PEX11A peroxisomal biogenesis factor 11 alpha 3.10738
TIMP2 TIMP metallopeptidase inhibitor 2 3.04923
EAPP E2F-associated phosphoprotein 2.9712
UGDH UDP-glucose 6-dehydrogenase 2.94395
SNAP25 synaptosomal-associated protein, 25kDa 2.88059
CERK ceramide kinase 2.64004
INSIG1 insulin induced gene 1 2.44116
ABHD6 abhydrolase domain containing 6 2.42787
CXCR4 chemokine (C-X-C motif) receptor 4 2.39383
NEUROD6 neuronal differentiation 6 2.36986
GLRX glutaredoxin (thioltransferase) 2.36546
PCDHB11 protocadherin beta 11 2.33039
NPTXR neuronal pentraxin receptor 2.23606
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.23353
SCGB2A2 secretoglobin, family 2A, member 2 2.20147
SPTSSA serine palmitoyltransferase, small subunit A 2.16449
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.1323
FCMR Fc fragment of IgM receptor 2.09793
SNCB synuclein, beta 2.07164
NSG2 neuronal vesicle trafficking associated 2 2.02755
TRIB3 tribbles pseudokinase 3 2.0269

decreased expression

Symbol Name Standardized Value
CCDC86 coiled-coil domain containing 86 -4.10799
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.51437
YME1L1 YME1-like 1 ATPase -3.28508
FAIM Fas apoptotic inhibitory molecule -3.15978
CD81 CD81 molecule -3.10297
RALGDS ral guanine nucleotide dissociation stimulator -3.03226
HMG20B high mobility group 20B -3.01995
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.92842
HOXA5 homeobox A5 -2.76607
DUSP14 dual specificity phosphatase 14 -2.62834
THAP11 THAP domain containing 11 -2.55318
IFRD2 interferon-related developmental regulator 2 -2.4689
CD58 CD58 molecule -2.45146
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.40616
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -2.39642
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 -2.28807
ISOC1 isochorismatase domain containing 1 -2.21027
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.07786
PLK2 polo-like kinase 2 -2.07155