CRCGN015_MCF10A.WT.HP_24H:E12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-methyl?aniline) 11.22 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:E12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 6.8366
TLR4 toll-like receptor 4 3.64768
MAMLD1 mastermind-like domain containing 1 3.45754
CHMP6 charged multivesicular body protein 6 3.31881
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.2143
GLOD4 glyoxalase domain containing 4 2.99676
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.87595
GSPT2 G1 to S phase transition 2 2.70202
HBA1 hemoglobin, alpha 1 2.49674
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.46256
CCNF cyclin F 2.43197
TSPAN8 tetraspanin 8 2.27473
ZNF365 zinc finger protein 365 2.27164
NRBF2 nuclear receptor binding factor 2 2.22072
DUSP3 dual specificity phosphatase 3 2.18105
CCN6 cellular communication network factor 6 2.12751
SPAG6 sperm associated antigen 6 2.12583
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.12094
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.1034
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.05337
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 2.0259

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -6.60862
TES testin LIM domain protein -3.51008
CTNND1 catenin (cadherin-associated protein), delta 1 -3.41282
COG2 component of oligomeric golgi complex 2 -2.97931
RNF167 ring finger protein 167 -2.94606
PTK2 protein tyrosine kinase 2 -2.80531
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.63563
GDF15 growth differentiation factor 15 -2.39162
ATG3 autophagy related 3 -2.37951
FASN fatty acid synthase -2.30708
PFN1 profilin 1 -2.29862
NLRP4 NLR family, pyrin domain containing 4 -2.23256
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.20844
VDAC1 voltage-dependent anion channel 1 -2.18872
PGCKA1 PDCD10 and GCKIII kinases associated 1 -2.14373
CAV1 caveolin 1, caveolae protein, 22kDa -2.13997
RGS19 regulator of G-protein signaling 19 -2.1051
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -2.02699