CRCGN015_MCF10A.WT.HP_24H:E17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description propyl gallate 33.49 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

191 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:E17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 5.65995
TXNRD1 thioredoxin reductase 1 4.98217
ABHD4 abhydrolase domain containing 4 4.58871
CAPN1 calpain 1, (mu/I) large subunit 4.15825
NUCB2 nucleobindin 2 4.11807
GARRE1 granule associated Rac and RHOG effector 1 3.56405
LYN LYN proto-oncogene, Src family tyrosine kinase 3.39165
ALAS1 5'-aminolevulinate synthase 1 3.33139
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.27917
WIF1 WNT inhibitory factor 1 3.1904
SQSTM1 sequestosome 1 3.18532
CCNA1 cyclin A1 3.05206
CRELD2 cysteine-rich with EGF-like domains 2 3.00741
SYNE2 spectrin repeat containing, nuclear envelope 2 2.96966
MINDY1 MINDY lysine 48 deubiquitinase 1 2.90984
MUC1 mucin 1, cell surface associated 2.90263
GLRX glutaredoxin (thioltransferase) 2.73746
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.68034
METTL25B methyltransferase like 25B 2.63975
IGFBP3 insulin-like growth factor binding protein 3 2.63889
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.60983
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2.56775
LOC114841035 uncharacterized LOC114841035 2.51528
UGDH UDP-glucose 6-dehydrogenase 2.43724
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.4329
IRF9 interferon regulatory factor 9 2.39821
SLC38A10 solute carrier family 38, member 10 2.38688
IL23A interleukin 23, alpha subunit p19 2.37891
PON3 paraoxonase 3 2.37167
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 2.34782
AGR2 anterior gradient 2 2.34685
NFE2 nuclear factor, erythroid 2 2.27395
CALCOCO1 calcium binding and coiled-coil domain 1 2.25553
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.25138
LCK LCK proto-oncogene, Src family tyrosine kinase 2.22844
NMRK1 nicotinamide riboside kinase 1 2.21434
PRSS16 protease, serine, 16 (thymus) 2.206
PGPEP1 pyroglutamyl-peptidase I 2.20364
SIRT7 sirtuin 7 2.19163
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.18873
SDF2L1 stromal cell-derived factor 2-like 1 2.17646
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.15677
SCPEP1 serine carboxypeptidase 1 2.14967
ANO10 anoctamin 10 2.14894
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.14517
SLC67A1 solute carrier family 67 member 1 2.13963
RGCC regulator of cell cycle 2.1359
RASL11B RAS-like, family 11, member B 2.1284
IL21R interleukin 21 receptor 2.12749
ARSA arylsulfatase A 2.11686
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 2.11057
CDC50B cell division cycle 50 P4-ATPase accessory subunit B 2.10909
DEPDC5 DEP domain containing 5 2.10706
HHIPL2 HHIP-like 2 2.10551
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.0984
CRABP2 cellular retinoic acid binding protein 2 2.07727
DUSP4 dual specificity phosphatase 4 2.07403
USP18 ubiquitin specific peptidase 18 2.07382
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.07113
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.05676
CST1 cystatin SN 2.04729
GNA14 guanine nucleotide binding protein (G protein), alpha 14 2.04566
DAD1 defender against cell death 1 2.04004
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.03722
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.03076
MYH9 myosin, heavy chain 9, non-muscle 2.01854
GSTA1 glutathione S-transferase alpha 1 2.00563
MAP3K11 mitogen-activated protein kinase kinase kinase 11 2.0033
AMT aminomethyltransferase 2.00087
GLOD4 glyoxalase domain containing 4 2.00086

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -4.98625
DCK deoxycytidine kinase -4.82182
UBE2C ubiquitin-conjugating enzyme E2C -4.78353
SMNDC1 survival motor neuron domain containing 1 -4.60451
PCNA proliferating cell nuclear antigen -4.53364
THAP11 THAP domain containing 11 -4.2724
PSRC1 proline/serine-rich coiled-coil 1 -4.18678
PLK1 polo-like kinase 1 -4.11863
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -4.09369
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.05846
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.96684
AURKA aurora kinase A -3.9122
VDAC1 voltage-dependent anion channel 1 -3.77843
CCNA2 cyclin A2 -3.69723
PSIP1 PC4 and SFRS1 interacting protein 1 -3.59248
KDM3A lysine (K)-specific demethylase 3A -3.46882
UFM1 ubiquitin-fold modifier 1 -3.44976
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.36558
SNRPB2 small nuclear ribonucleoprotein polypeptide B -3.35771
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.27964
RNASE7 ribonuclease, RNase A family, 7 -3.27086
ARPP19 cAMP-regulated phosphoprotein, 19kDa -3.1073
PRELID3B PRELI domain containing 3B -2.9782
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.9573
KIF14 kinesin family member 14 -2.90353
CDCA4 cell division cycle associated 4 -2.89105
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.84171
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.81387
STMN1 stathmin 1 -2.76523
TOP2A topoisomerase (DNA) II alpha 170kDa -2.75182
KIF1B kinesin family member 1B -2.73702
PARP2 poly (ADP-ribose) polymerase 2 -2.72639
RPP30 ribonuclease P/MRP 30kDa subunit -2.68964
HDAC2 histone deacetylase 2 -2.68084
TPX2 TPX2, microtubule-associated -2.65418
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.65268
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.64427
CDK1 cyclin-dependent kinase 1 -2.64343
BIRC5 baculoviral IAP repeat containing 5 -2.64009
PCCB propionyl CoA carboxylase, beta polypeptide -2.59573
ECD ecdysoneless homolog (Drosophila) -2.57823
PFN1 profilin 1 -2.57809
RUVBL1 RuvB-like AAA ATPase 1 -2.56954
KIF20A kinesin family member 20A -2.55103
GEMIN2 gem (nuclear organelle) associated protein 2 -2.53188
HSPA14 heat shock 70kDa protein 14 -2.5278
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -2.52195
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.51086
GTF2A2 general transcription factor IIA, 2, 12kDa -2.50974
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.50642
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.49531
MCM3 minichromosome maintenance complex component 3 -2.48472
SPDL1 spindle apparatus coiled-coil protein 1 -2.47933
KIF4A kinesin family member 4A -2.47763
RPL39L ribosomal protein L39-like -2.4534
CD320 CD320 molecule -2.4375
EXOSC9 exosome component 9 -2.38161
RACGAP1 Rac GTPase activating protein 1 -2.36655
GTPBP8 GTP-binding protein 8 (putative) -2.36555
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.34438
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -2.34308
MED4 mediator complex subunit 4 -2.30275
HJURP Holliday junction recognition protein -2.29673
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.28321
NXT1 nuclear transport factor 2-like export factor 1 -2.28092
TBCCD1 TBCC domain containing 1 -2.27932
TACC3 transforming, acidic coiled-coil containing protein 3 -2.27916
CRYZ crystallin, zeta (quinone reductase) -2.2768
NUP85 nucleoporin 85kDa -2.25811
SPPL2A signal peptide peptidase like 2A -2.25197
MTERF3 mitochondrial transcription termination factor 3 -2.25142
CERS1 ceramide synthase 1 -2.24938
INPP1 inositol polyphosphate-1-phosphatase -2.24658
PNRC2 proline-rich nuclear receptor coactivator 2 -2.24553
CDCA8 cell division cycle associated 8 -2.24498
AAR2 AAR2 splicing factor homolog (S. cerevisiae) -2.24361
PPIE peptidylprolyl isomerase E (cyclophilin E) -2.24247
TOMM34 translocase of outer mitochondrial membrane 34 -2.23607
ADNP activity-dependent neuroprotector homeobox -2.23239
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) -2.22667
PARG poly (ADP-ribose) glycohydrolase -2.20895
ZNF106 zinc finger protein 106 -2.19605
UBA2 ubiquitin-like modifier activating enzyme 2 -2.19055
EIF4E eukaryotic translation initiation factor 4E -2.17864
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.16914
CCNF cyclin F -2.15486
CCNB1 cyclin B1 -2.15002
MED7 mediator complex subunit 7 -2.14919
FRG1 FSHD region gene 1 -2.14362
STXBP3 syntaxin binding protein 3 -2.13731
SOCS5 suppressor of cytokine signaling 5 -2.12141
CDK4 cyclin-dependent kinase 4 -2.12086
SEC23A Sec23 homolog A (S. cerevisiae) -2.11484
DBR1 debranching RNA lariats 1 -2.1147
TNNC1 troponin C type 1 (slow) -2.11327
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.1052
CETN3 centrin, EF-hand protein, 3 -2.10167
PPID peptidylprolyl isomerase D -2.08895
THOC7 THO complex 7 -2.08354
DBF4 DBF4 zinc finger -2.08266
NUSAP1 nucleolar and spindle associated protein 1 -2.08124
DCPH1 damage control phosphatase 1 -2.07601
COMMD3-BMI1 COMMD3-BMI1 readthrough -2.07441
BICD2 bicaudal D homolog 2 (Drosophila) -2.06909
AUNIP aurora kinase A and ninein interacting protein -2.06554
HADH hydroxyacyl-CoA dehydrogenase -2.06365
CPEB1 cytoplasmic polyadenylation element binding protein 1 -2.05669
TMEM38B transmembrane protein 38B -2.0498
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.04841
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.04762
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.04367
PTK2 protein tyrosine kinase 2 -2.03828
LBR lamin B receptor -2.0379
CCDC59 coiled-coil domain containing 59 -2.03327
NIPSNAP2 nipsnap homolog 2 -2.03225
DSN1 DSN1, MIS12 kinetochore complex component -2.02776
INTS12 integrator complex subunit 12 -2.02476
CYCS cytochrome c, somatic -2.02198
GPN3 GPN-loop GTPase 3 -2.00958
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.00402
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.0025