CRCGN015_MCF10A.WT.HP_24H:E22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description norethindrone 100.09 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:E22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 5.55115
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 4.2329
EPN2 epsin 2 3.82192
BAMBI BMP and activin membrane-bound inhibitor 2.6907
GPATCH8 G patch domain containing 8 2.67125
GPR20 G protein-coupled receptor 20 2.6306
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.59465
SSTR5 somatostatin receptor 5 2.5905
MYH13 myosin, heavy chain 13, skeletal muscle 2.5195
HIC1 hypermethylated in cancer 1 2.46215
FLT3LG fms-related tyrosine kinase 3 ligand 2.44155
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.4003
PDE3A phosphodiesterase 3A, cGMP-inhibited 2.3908
HOXA6 homeobox A6 2.3892
MAPK4 mitogen-activated protein kinase 4 2.36845
STK10 serine/threonine kinase 10 2.27623
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.2738
FGF8 fibroblast growth factor 8 (androgen-induced) 2.2427
NMUR1 neuromedin U receptor 1 2.23365
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.2089
CBARP CACN subunit beta associated regulatory protein 2.1802
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.1669
XPO4 exportin 4 2.1624
FBXO24 F-box protein 24 2.1494
MBNL3 muscleblind-like splicing regulator 3 2.1486
MTMR12 myotubularin related protein 12 2.13025
PCDHGA11 protocadherin gamma subfamily A, 11 2.126
FBXO11 F-box protein 11 2.1175
DUSP4 dual specificity phosphatase 4 2.1167
SPATA31C1 SPATA31 subfamily C, member 1 2.0991
ACE angiotensin I converting enzyme 2.095
LRRC37A3 leucine rich repeat containing 37, member A3 2.08365
FSCN2 fascin actin-bundling protein 2, retinal 2.0608
PVR poliovirus receptor 2.03653
USP36 ubiquitin specific peptidase 36 2.03145
HAS2 hyaluronan synthase 2 2.0282
LHX5 LIM homeobox 5 2.01605
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.0104
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.0065
IER3 immediate early response 3 2.0043

decreased expression

Symbol Name Standardized Value
RGS2 regulator of G-protein signaling 2 -5.5255
CDK4 cyclin-dependent kinase 4 -5.4851
PPIC peptidylprolyl isomerase C (cyclophilin C) -4.818
TXNDC9 thioredoxin domain containing 9 -4.7562
GADD45B growth arrest and DNA-damage-inducible, beta -3.74307
CREG1 cellular repressor of E1A-stimulated genes 1 -3.543
BASP1 brain abundant, membrane attached signal protein 1 -3.30365
TSPAN31 tetraspanin 31 -2.59855
OXA1L oxidase (cytochrome c) assembly 1-like -2.4586
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.44245
METTL1 methyltransferase like 1 -2.37435
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.3724
EIF5B eukaryotic translation initiation factor 5B -2.36456
TSC22D3 TSC22 domain family, member 3 -2.27965
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.26595
ADRB2 adrenoceptor beta 2, surface -2.2457
UNC50 unc-50 homolog (C. elegans) -2.19925
MRFAP1L1 Morf4 family associated protein 1-like 1 -2.17695
TMEM50A transmembrane protein 50A -2.1035
EEF1AKMT3 EEF1A lysine methyltransferase 3 -2.0647
C1GALT1C1 C1GALT1-specific chaperone 1 -2.0559