CRCGN015_MCF10A.WT.HP_24H:E24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description norethindrone 11.12 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

24 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:E24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.35835
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.02226
RPP38 ribonuclease P/MRP 38kDa subunit 2.80073
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.77482
CCL2 chemokine (C-C motif) ligand 2 2.73805
MTA2 metastasis associated 1 family, member 2 2.38146
COMP cartilage oligomeric matrix protein 2.28922
CRTC3 CREB regulated transcription coactivator 3 2.21725
TBXA2R thromboxane A2 receptor 2.12246
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.10104
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.077
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.03689

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.64457
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.09698
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -3.01401
THAP11 THAP domain containing 11 -2.87987
CREG1 cellular repressor of E1A-stimulated genes 1 -2.8649
ALDOC aldolase C, fructose-bisphosphate -2.51304
LYPLA1 lysophospholipase I -2.50118
CREB1 cAMP responsive element binding protein 1 -2.36602
TES testin LIM domain protein -2.35408
SCYL3 SCY1-like 3 (S. cerevisiae) -2.15798
KDM3A lysine (K)-specific demethylase 3A -2.0599
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.04312