CRCGN015_MCF10A.WT.HP_24H:F03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diethylstilbestrol 11.16 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:F03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.76905
GRB10 growth factor receptor-bound protein 10 3.19497
COMP cartilage oligomeric matrix protein 2.94813
ACAA1 acetyl-CoA acyltransferase 1 2.26709
AGR2 anterior gradient 2 2.16353
ADCY7 adenylate cyclase 7 2.08042
HOXA5 homeobox A5 2.02598
IDE insulin-degrading enzyme 2.0116

decreased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 -8.29387
ZDHHC6 zinc finger, DHHC-type containing 6 -4.73257
HMG20B high mobility group 20B -4.67139
HAT1 histone acetyltransferase 1 -4.3179
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.06303
TNIP1 TNFAIP3 interacting protein 1 -3.84559
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.55322
ATF5 activating transcription factor 5 -2.80913
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.75024
VDAC1 voltage-dependent anion channel 1 -2.56315
PRR15L proline rich 15-like -2.52606
WNT5A wingless-type MMTV integration site family, member 5A -2.4768
TKT transketolase -2.40366
QTMAN queuosine-tRNA mannosyltransferase -2.29794
PCBP1 poly(rC) binding protein 1 -2.28846
S100A14 S100 calcium binding protein A14 -2.2632
KLRC3 killer cell lectin-like receptor subfamily C, member 3 -2.2247
ZFP37 ZFP37 zinc finger protein -2.2053
IFRD2 interferon-related developmental regulator 2 -2.1868
MMUT methylmalonyl-CoA mutase -2.15905
BPHL biphenyl hydrolase-like (serine hydrolase) -2.14998
CIRSR corepressor of RBPJ and splicing regulator -2.14499
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -2.13687
HSPA1A heat shock 70kDa protein 1A -2.11746
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 -2.10907
CSN1S1 casein alpha s1 -2.08113
ALDOC aldolase C, fructose-bisphosphate -2.07827
NCAM2 neural cell adhesion molecule 2 -2.07064
NELFE negative elongation factor complex member E -2.05484
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -2.00876