CRCGN015_MCF10A.WT.HP_24H:F04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K63993117 102.48 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

98 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:F04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNRIP1 cannabinoid receptor interacting protein 1 4.922
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.91857
MAP7 microtubule-associated protein 7 4.42582
AGR2 anterior gradient 2 4.08436
C2CD2 C2 calcium-dependent domain containing 2 4.0109
UBQLN2 ubiquilin 2 3.65191
IL1B interleukin 1, beta 3.41197
DHDDS dehydrodolichyl diphosphate synthase 2.80791
IDE insulin-degrading enzyme 2.79855
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.76368
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.67392
VRTN vertebrae development associated 2.61164
COMP cartilage oligomeric matrix protein 2.60477
NELL2 NEL-like 2 (chicken) 2.56922
TULP4 tubby like protein 4 2.55591
VWF von Willebrand factor 2.51019
AGO1 argonaute RISC catalytic component 1 2.4193
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.41772
GJA4 gap junction protein, alpha 4, 37kDa 2.39309
GSTK1 glutathione S-transferase kappa 1 2.39099
NPIPB6 nuclear pore complex interacting protein family, member B6 2.35623
ACAD10 acyl-CoA dehydrogenase family, member 10 2.31753
TM4SF20 transmembrane 4 L six family member 20 2.31441
TTC12 tetratricopeptide repeat domain 12 2.29701
TH tyrosine hydroxylase 2.29672
RTN3 reticulon 3 2.28944
MNS1 meiosis-specific nuclear structural 1 2.26138
TUBA3C tubulin, alpha 3c 2.24113
ARL4A ADP-ribosylation factor-like 4A 2.23479
SPA17 sperm autoantigenic protein 17 2.22407
TASL TLR adaptor interacting with endolysosomal SLC15A4 2.20814
SYNM synemin, intermediate filament protein 2.19091
MXD1 MAX dimerization protein 1 2.18696
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 2.18082
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.14123
IL22 interleukin 22 2.14067
IL18 interleukin 18 2.13773
CRYBG3 beta-gamma crystallin domain containing 3 2.12249
ODF2 outer dense fiber of sperm tails 2 2.11051
NLGN4X neuroligin 4, X-linked 2.10395
BICRAL BICRA like chromatin remodeling complex associated protein 2.08144
ZNF35 zinc finger protein 35 2.07787
CTSZ cathepsin Z 2.0757
CDCP1 CUB domain containing protein 1 2.0725
MCAM melanoma cell adhesion molecule 2.06929
CRLF3 cytokine receptor-like factor 3 2.05999
ASIC1 acid sensing (proton gated) ion channel 1 2.05584
HEBP2 heme binding protein 2 2.05286
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 2.05069
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 2.04764
CD1D CD1d molecule 2.03554
COL17A1 collagen, type XVII, alpha 1 2.01955
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 2.01436
LRRN3 leucine rich repeat neuronal 3 2.00664
CCR2 chemokine (C-C motif) receptor 2 2.00476

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -7.25051
GDF15 growth differentiation factor 15 -5.67557
TIMP1 TIMP metallopeptidase inhibitor 1 -4.91326
NPDC1 neural proliferation, differentiation and control, 1 -4.65257
COG2 component of oligomeric golgi complex 2 -4.57008
HMG20B high mobility group 20B -4.40591
CCNB1 cyclin B1 -4.09357
NUP85 nucleoporin 85kDa -3.82043
MSMO1 methylsterol monooxygenase 1 -3.03313
NT5DC2 5'-nucleotidase domain containing 2 -3.02181
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.91089
HMOX2 heme oxygenase 2 -2.71432
MRPS7 mitochondrial ribosomal protein S7 -2.65597
TMEM165 transmembrane protein 165 -2.63428
CHMP7 charged multivesicular body protein 7 -2.58251
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.57755
GREB1L growth regulation by estrogen in breast cancer-like -2.5547
CAB39 calcium binding protein 39 -2.42446
FAM193B family with sequence similarity 193, member B -2.38312
PCID2 PCI domain containing 2 -2.35472
FSTL1 follistatin-like 1 -2.35268
TASOR2 transcription activation suppressor family member 2 -2.35113
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.34057
HAGH hydroxyacylglutathione hydrolase -2.29622
TIMP3 TIMP metallopeptidase inhibitor 3 -2.26293
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 -2.26203
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.25047
HLA-A major histocompatibility complex, class I, A -2.24303
HAX1 HCLS1 associated protein X-1 -2.20937
CYB5A cytochrome b5 type A (microsomal) -2.20033
FCMR Fc fragment of IgM receptor -2.19935
GABARAP GABA(A) receptor-associated protein -2.17596
VMP1 vacuole membrane protein 1 -2.15922
ABI2 abl-interactor 2 -2.14781
NPIPB5 nuclear pore complex interacting protein family, member B5 -2.13494
GPX4 glutathione peroxidase 4 -2.10359
HEXB hexosaminidase B (beta polypeptide) -2.09788
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 -2.0849
LCAT lecithin-cholesterol acyltransferase -2.06941
TMSB15C thymosin beta 15C -2.06792
CD81 CD81 molecule -2.05961
KCTD3 potassium channel tetramerization domain containing 3 -2.05271
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.01465