CRCGN015_MCF10A.WT.HP_24H:F08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hexachlorocyclopentadiene 33.82 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

146 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:F08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LGMN legumain 5.62178
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 5.34686
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.39244
SPAG4 sperm associated antigen 4 4.16684
NISCH nischarin 4.0179
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.90162
STK10 serine/threonine kinase 10 3.85158
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.72582
MKNK1 MAP kinase interacting serine/threonine kinase 1 3.57949
LYN LYN proto-oncogene, Src family tyrosine kinase 3.54981
AGR2 anterior gradient 2 3.40062
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 3.37248
TSPAN6 tetraspanin 6 3.21391
C5 complement component 5 3.19212
AMDHD2 amidohydrolase domain containing 2 3.01224
WIF1 WNT inhibitory factor 1 2.91165
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.8458
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.83017
BCL2 B-cell CLL/lymphoma 2 2.74434
LUC7L LUC7-like (S. cerevisiae) 2.70448
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.66671
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 2.65756
RYR3 ryanodine receptor 3 2.64498
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.62463
HOXA6 homeobox A6 2.55905
SORBS1 sorbin and SH3 domain containing 1 2.5187
CAPN6 calpain 6 2.51488
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.48433
TERT telomerase reverse transcriptase 2.47393
PRR7 proline rich 7 (synaptic) 2.46253
MSRA methionine sulfoxide reductase A 2.46193
GRB10 growth factor receptor-bound protein 10 2.43261
VASH2 vasohibin 2 2.42129
MSX1 msh homeobox 1 2.4026
PKD2L1 polycystic kidney disease 2-like 1 2.38245
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.36815
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.35303
SYK spleen tyrosine kinase 2.34491
MTUS2 microtubule associated tumor suppressor candidate 2 2.33327
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 2.33287
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.33079
ARHGAP26 Rho GTPase activating protein 26 2.32198
KIF25 kinesin family member 25 2.30826
UPK3A uroplakin 3A 2.28441
CD8B CD8b molecule 2.27511
NLGN1 neuroligin 1 2.27209
PHF13 PHD finger protein 13 2.2692
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.25734
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.25361
KLRC4 killer cell lectin-like receptor subfamily C, member 4 2.24073
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.23884
DRC4 dynein regulatory complex subunit 4 2.23775
KLHL29 kelch-like family member 29 2.23202
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 2.22962
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 2.22396
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 2.22154
MLEC malectin 2.2142
SOX17 SRY (sex determining region Y)-box 17 2.20894
TESC tescalcin 2.2054
KLHDC4 kelch domain containing 4 2.19557
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.18799
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.18778
DPF3 D4, zinc and double PHD fingers, family 3 2.18245
CSN1S1 casein alpha s1 2.17572
DNAH7 dynein, axonemal, heavy chain 7 2.17477
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.16189
MYBPC1 myosin binding protein C, slow type 2.1582
NELFCD negative elongation factor complex member C/D 2.15238
SLC66A3 solute carrier family 66 member 3 2.14743
USP18 ubiquitin specific peptidase 18 2.14025
A2M alpha-2-macroglobulin 2.12602
PI15 peptidase inhibitor 15 2.11405
CCDC106 coiled-coil domain containing 106 2.11209
ADISSP adipose secreted signaling protein 2.10559
EPCIP exosomal polycystin 1 interacting protein 2.10422
FPGS folylpolyglutamate synthase 2.10181
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.09256
ACSL5 acyl-CoA synthetase long-chain family member 5 2.08751
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 2.08177
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.08176
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.06364
PZP pregnancy-zone protein 2.06265
MEOX2 mesenchyme homeobox 2 2.06133
MNMIP1 manchette microtubule inner protein 1 2.05197
PDZK1 PDZ domain containing 1 2.05015
SPRY4 sprouty homolog 4 (Drosophila) 2.04873
LOC122526780 uncharacterized LOC122526780 2.04562
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.04509
KLRC4-KLRK1 KLRC4-KLRK1 readthrough 2.04372
EYA1 EYA transcriptional coactivator and phosphatase 1 2.04284
ACE angiotensin I converting enzyme 2.04244
HLA-DMA major histocompatibility complex, class II, DM alpha 2.04232
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 2.04007
CGB8 chorionic gonadotropin, beta polypeptide 8 2.03704
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 2.03679
STUM stum, mechanosensory transduction mediator homolog 2.03374
TLR4 toll-like receptor 4 2.03113
FLT4 fms-related tyrosine kinase 4 2.02636
PLEKHO1 pleckstrin homology domain containing, family O member 1 2.022
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 2.02106
LPCAT1 lysophosphatidylcholine acyltransferase 1 2.02041
FRS2 fibroblast growth factor receptor substrate 2 2.01835
EYA4 EYA transcriptional coactivator and phosphatase 4 2.01559
TLE4 transducin-like enhancer of split 4 2.01223
MMP26 matrix metallopeptidase 26 2.01007

decreased expression

Symbol Name Standardized Value
SLC25A46 solute carrier family 25, member 46 -4.36844
S100A8 S100 calcium binding protein A8 -3.8444
MSMO1 methylsterol monooxygenase 1 -3.83696
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.7328
MRPS2 mitochondrial ribosomal protein S2 -3.68217
SCYL3 SCY1-like 3 (S. cerevisiae) -3.63833
PFN1 profilin 1 -3.44987
UBE3C ubiquitin protein ligase E3C -3.3028
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.06908
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.02372
UFM1 ubiquitin-fold modifier 1 -2.98846
REEP5 receptor accessory protein 5 -2.86391
CD44 CD44 molecule (Indian blood group) -2.83002
TMEM267 transmembrane protein 267 -2.7097
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.6416
CAB39 calcium binding protein 39 -2.48221
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.44015
UCK2 uridine-cytidine kinase 2 -2.43664
SH3D19 SH3 domain containing 19 -2.36326
STN1 STN1 subunit of CST complex -2.33057
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator -2.29347
KLHL12 kelch-like family member 12 -2.23533
CREG1 cellular repressor of E1A-stimulated genes 1 -2.20155
PPA1 pyrophosphatase (inorganic) 1 -2.20085
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -2.17395
COQ4 coenzyme Q4 -2.14543
SUSD6 sushi domain containing 6 -2.14143
CCDC6 coiled-coil domain containing 6 -2.13108
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -2.11964
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.10619
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.10496
STAMBP STAM binding protein -2.09573
BASP1 brain abundant, membrane attached signal protein 1 -2.0932
COMMD3 COMM domain containing 3 -2.08333
FKBP14 FK506 binding protein 14, 22 kDa -2.06858
DCTN6 dynactin 6 -2.06726
TKT transketolase -2.06286
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -2.05193
VAMP7 vesicle-associated membrane protein 7 -2.04292
DEFB1 defensin, beta 1 -2.0194
NELFB negative elongation factor complex member B -2.01748