CRCGN015_MCF10A.WT.HP_24H:F09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hexachlorocyclopentadiene 11.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

157 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:F09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 9.51375
MAMLD1 mastermind-like domain containing 1 5.19927
WFS1 Wolfram syndrome 1 (wolframin) 5.01068
SPAG4 sperm associated antigen 4 4.92605
SSBP2 single-stranded DNA binding protein 2 4.9076
LAGE3 L antigen family, member 3 4.39895
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.14489
KIF5C kinesin family member 5C 3.91231
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.6763
PRKCH protein kinase C, eta 3.55327
BAX BCL2-associated X protein 2.89838
GC group-specific component (vitamin D binding protein) 2.71796
LAG3 lymphocyte-activation gene 3 2.71727
ZNF711 zinc finger protein 711 2.65874
IL12A interleukin 12A 2.6491
METRN meteorin, glial cell differentiation regulator 2.64802
PTPRJ protein tyrosine phosphatase, receptor type, J 2.64396
ALLC allantoicase 2.6258
TTPA tocopherol (alpha) transfer protein 2.61324
ADGRB3 adhesion G protein-coupled receptor B3 2.60943
SMCP sperm mitochondria-associated cysteine-rich protein 2.59661
ASTN1 astrotactin 1 2.55606
WIF1 WNT inhibitory factor 1 2.55442
GPR20 G protein-coupled receptor 20 2.54552
RPL10L ribosomal protein L10-like 2.54358
TMPRSS11E transmembrane protease, serine 11E 2.48583
PDZRN4 PDZ domain containing ring finger 4 2.48391
MELTF melanotransferrin 2.48141
CCDC70 coiled-coil domain containing 70 2.44953
IL4 interleukin 4 2.43176
APOC3 apolipoprotein C-III 2.42865
FGF16 fibroblast growth factor 16 2.42733
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.41674
MROH7 maestro heat-like repeat family member 7 2.41296
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.36376
EPB41 erythrocyte membrane protein band 4.1 2.36092
UPK1A uroplakin 1A 2.35062
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) 2.34462
ONECUT2 one cut homeobox 2 2.33243
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.32667
RFX4 regulatory factor X, 4 (influences HLA class II expression) 2.31482
MTA2 metastasis associated 1 family, member 2 2.29361
KLHL29 kelch-like family member 29 2.28269
RGSL1 regulator of G-protein signaling like 1 2.27973
BCAN brevican 2.27662
CSRNP3 cysteine-serine-rich nuclear protein 3 2.27634
MTUS2 microtubule associated tumor suppressor candidate 2 2.26919
MAB21L4 mab-21 like 4 2.25718
SOX5 SRY (sex determining region Y)-box 5 2.24865
TCHH trichohyalin 2.24114
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.23503
CPB2 carboxypeptidase B2 (plasma) 2.23279
ZNF385D zinc finger protein 385D 2.2274
ECEL1 endothelin converting enzyme-like 1 2.22157
BTN1A1 butyrophilin, subfamily 1, member A1 2.20846
BLMH bleomycin hydrolase 2.20142
OR1A1 olfactory receptor, family 1, subfamily A, member 1 2.19831
CCL7 chemokine (C-C motif) ligand 7 2.19512
POU3F4 POU class 3 homeobox 4 2.19402
NPAS3 neuronal PAS domain protein 3 2.19234
ATXN3L ataxin 3-like 2.19135
FOXE3 forkhead box E3 2.18767
MSH5 mutS homolog 5 2.1875
YOD1 YOD1 deubiquitinase 2.1836
ENDOU endonuclease, polyU-specific 2.18332
SCRG1 stimulator of chondrogenesis 1 2.18092
CRYBA4 crystallin, beta A4 2.17544
RXFP3 relaxin/insulin-like family peptide receptor 3 2.16875
CLEC2D C-type lectin domain family 2, member D 2.16723
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.16504
CFHR2 complement factor H-related 2 2.15773
SYNGR4 synaptogyrin 4 2.15574
ODF1 outer dense fiber of sperm tails 1 2.15434
PBOV1 prostate and breast cancer overexpressed 1 2.15232
PHF10 PHD finger protein 10 2.15029
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.14876
SPATA6L spermatogenesis associated 6-like 2.14873
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 2.148
TSPO2 translocator protein 2 2.14779
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.14399
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 2.13615
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) 2.13445
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2.12893
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.12061
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 2.11706
CDH20 cadherin 20, type 2 2.11555
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.11467
TACR3 tachykinin receptor 3 2.10963
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.10126
ZFY zinc finger protein, Y-linked 2.10072
GML glycosylphosphatidylinositol anchored molecule like 2.1006
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.10053
LDHAL6B lactate dehydrogenase A-like 6B 2.09794
SLITRK2 SLIT and NTRK-like family, member 2 2.0966
GPR171 G protein-coupled receptor 171 2.09343
ACRV1 acrosomal vesicle protein 1 2.09291
GALR1 galanin receptor 1 2.09206
CDH10 cadherin 10, type 2 (T2-cadherin) 2.09114
CATSPERG catsper channel auxiliary subunit gamma 2.08875
CPNE2 copine II 2.08747
DLL3 delta-like 3 (Drosophila) 2.08648
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.08504
IFNB1 interferon, beta 1, fibroblast 2.08501
BMP15 bone morphogenetic protein 15 2.08094
PARD6B par-6 family cell polarity regulator beta 2.07639
DDB1 damage-specific DNA binding protein 1, 127kDa 2.07527
CRHR2 corticotropin releasing hormone receptor 2 2.07427
IL12RB2 interleukin 12 receptor, beta 2 2.07242
OR2J3 olfactory receptor, family 2, subfamily J, member 3 2.06479
S100A5 S100 calcium binding protein A5 2.06404
OR1G1 olfactory receptor, family 1, subfamily G, member 1 2.06236
CRYGA crystallin, gamma A 2.05886
AFF3 AF4/FMR2 family, member 3 2.05719
ASIC3 acid sensing (proton gated) ion channel 3 2.05223
SPMAP2 sperm microtubule associated protein 2 2.05192
FOXN1 forkhead box N1 2.04762
TSBP1 testis expressed basic protein 1 2.04517
KRTAP5-3 keratin associated protein 5-3 2.0413
PCDHGA1 protocadherin gamma subfamily A, 1 2.03735
ZNF250 zinc finger protein 250 2.03518
SEMG2 semenogelin II 2.03364
ZNF592 zinc finger protein 592 2.03225
ANP32D acidic (leucine-rich) nuclear phosphoprotein 32 family, member D 2.03048
VTN vitronectin 2.02986
ZNF185 zinc finger protein 185 (LIM domain) 2.02945
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.02908
PDE10A phosphodiesterase 10A 2.02611
KMT2D lysine (K)-specific methyltransferase 2D 2.02555
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.02508
VPREB1 pre-B lymphocyte 1 2.02478
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.01451
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.01196
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 2.007
EPB42 erythrocyte membrane protein band 4.2 2.0063
SNTG1 syntrophin, gamma 1 2.0049

decreased expression

Symbol Name Standardized Value
GTPBP8 GTP-binding protein 8 (putative) -4.94368
HSPA8 heat shock 70kDa protein 8 -4.56642
BASP1 brain abundant, membrane attached signal protein 1 -4.49012
PRPF4 pre-mRNA processing factor 4 -4.22399
CCNB1 cyclin B1 -4.16488
GDF15 growth differentiation factor 15 -3.53737
MTERF3 mitochondrial transcription termination factor 3 -2.76384
MSN moesin -2.71809
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.48843
IFNGR1 interferon gamma receptor 1 -2.48607
LMF2 lipase maturation factor 2 -2.38438
TMEM184B transmembrane protein 184B -2.23284
RIN3 Ras and Rab interactor 3 -2.22615
DUSP10 dual specificity phosphatase 10 -2.21801
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -2.21167
SPA17 sperm autoantigenic protein 17 -2.17847
SQSTM1 sequestosome 1 -2.14105
LGALS9C lectin, galactoside-binding, soluble, 9C -2.13764
LSG1 large 60S subunit nuclear export GTPase 1 -2.11288
PTPRK protein tyrosine phosphatase, receptor type, K -2.03327
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -2.02538
ENC1 ectodermal-neural cortex 1 (with BTB domain) -2.01546