CRCGN015_MCF10A.WT.HP_24H:F12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclohexylamine.hcl 11.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 6.58758
SPAG4 sperm associated antigen 4 3.74643
SNAP25 synaptosomal-associated protein, 25kDa 3.69558
EVL Enah/Vasp-like 3.66114
TSEN2 TSEN2 tRNA splicing endonuclease subunit 3.66039
MEF2C myocyte enhancer factor 2C 3.32032
IDE insulin-degrading enzyme 3.29553
CDCA4 cell division cycle associated 4 2.9457
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.86958
NSG2 neuronal vesicle trafficking associated 2 2.69802
CNRIP1 cannabinoid receptor interacting protein 1 2.63936
KDM5D lysine (K)-specific demethylase 5D 2.52852
TPD52L2 tumor protein D52-like 2 2.49771
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.28146
COX6C cytochrome c oxidase subunit VIc 2.26726
NEFL neurofilament, light polypeptide 2.10667
SQOR sulfide quinone oxidoreductase 2.09596
ATP5F1B ATP synthase F1 subunit beta 2.03784
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.00243

decreased expression

Symbol Name Standardized Value
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.1594
GDF15 growth differentiation factor 15 -4.15757
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.06552
UFM1 ubiquitin-fold modifier 1 -3.72341
MRPS2 mitochondrial ribosomal protein S2 -3.33959
SLC35F2 solute carrier family 35, member F2 -3.2833
HMG20B high mobility group 20B -3.2526
MSN moesin -3.07881
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.01501
PCNA proliferating cell nuclear antigen -2.95121
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.84538
COG2 component of oligomeric golgi complex 2 -2.73801
DPP4 dipeptidyl-peptidase 4 -2.47732
HTRA1 HtrA serine peptidase 1 -2.43992
PES1 pescadillo ribosomal biogenesis factor 1 -2.37095
KDM5C lysine (K)-specific demethylase 5C -2.32684
TSC1 tuberous sclerosis 1 -2.24974
COQ4 coenzyme Q4 -2.23848
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.23777
NSFL1C NSFL1 (p97) cofactor (p47) -2.22561
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -2.16969
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -2.10785
ATP11B ATPase, class VI, type 11B -2.09449
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.07642
PAEP progestagen-associated endometrial protein -2.02922
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.01153