CRCGN015_MCF10A.WT.HP_24H:F13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoic acid, sodium 101.47 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:F13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.60525
MYLK myosin light chain kinase 4.42785
AGR2 anterior gradient 2 4.35668
CNRIP1 cannabinoid receptor interacting protein 1 4.34414
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.12755
ZNF586 zinc finger protein 586 4.10398
ZNF134 zinc finger protein 134 3.93425
CXCR4 chemokine (C-X-C motif) receptor 4 3.76595
ZNF551 zinc finger protein 551 2.73354
SATB1 SATB homeobox 1 2.5878
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.50712
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 2.45867
LDLRAP1 low density lipoprotein receptor adaptor protein 1 2.37487
ZNF304 zinc finger protein 304 2.36017
S1PR1 sphingosine-1-phosphate receptor 1 2.34544
ITK IL2-inducible T-cell kinase 2.28705
DHDDS dehydrodolichyl diphosphate synthase 2.28661
TBX2 T-box 2 2.27915
GPR183 G protein-coupled receptor 183 2.25263
GIMAP4 GTPase, IMAP family member 4 2.20567
TLCD3A TLC domain containing 3A 2.18349
ACAA1 acetyl-CoA acyltransferase 1 2.17203
FYB1 FYN binding protein 1 2.16735
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.14431
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.1271
NUP43 nucleoporin 43kDa 2.10303
ZNF14 zinc finger protein 14 2.1029
MERTK MER proto-oncogene, tyrosine kinase 2.09342
GADD45B growth arrest and DNA-damage-inducible, beta 2.09059
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.07858
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 2.04729
FPR1 formyl peptide receptor 1 2.03761
PDCL3 phosducin-like 3 2.02633
APOO apolipoprotein O 2.00841
IFNAR2 interferon (alpha, beta and omega) receptor 2 2.00026

decreased expression

Symbol Name Standardized Value
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.23034
TNIP1 TNFAIP3 interacting protein 1 -3.91125
WASHC4 WASH complex subunit 4 -3.50592
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -3.21007
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.02456
CD81 CD81 molecule -2.87326
RBM15B RNA binding motif protein 15B -2.80083
TENT4A terminal nucleotidyltransferase 4A -2.66707
IPO13 importin 13 -2.65461
STAG3 stromal antigen 3 -2.36018
GULP1 GULP, engulfment adaptor PTB domain containing 1 -2.32651
ARHGAP17 Rho GTPase activating protein 17 -2.31254
CLCN6 chloride channel, voltage-sensitive 6 -2.23627
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.2195
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -2.18552
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -2.15973
TBK1 TANK-binding kinase 1 -2.12187
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -2.09428
AMOTL2 angiomotin like 2 -2.0776
WASF1 WAS protein family, member 1 -2.04414