CRCGN015_MCF10A.WT.HP_24H:F14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoic acid, sodium 33.82 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:F14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.60085
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 3.57778
WIF1 WNT inhibitory factor 1 3.50564
SNAP25 synaptosomal-associated protein, 25kDa 3.21075
COMP cartilage oligomeric matrix protein 2.79889
FGFR4 fibroblast growth factor receptor 4 2.72314
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.71202
CXCR2 chemokine (C-X-C motif) receptor 2 2.4686
SYT1 synaptotagmin I 2.40946
ACAA1 acetyl-CoA acyltransferase 1 2.38416
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.29477
UBE2H ubiquitin-conjugating enzyme E2H 2.21361
FAM3C family with sequence similarity 3, member C 2.17874
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.17431
STMN2 stathmin 2 2.14394
HBA1 hemoglobin, alpha 1 2.12665
CIAO3 cytosolic iron-sulfur assembly component 3 2.09298
CENPE centromere protein E, 312kDa 2.09093
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.08516
DENND2D DENN/MADD domain containing 2D 2.06901
CXCR4 chemokine (C-X-C motif) receptor 4 2.05053
NEFM neurofilament, medium polypeptide 2.03918

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -6.94596
GDF15 growth differentiation factor 15 -3.82513
NPDC1 neural proliferation, differentiation and control, 1 -3.77483
PCNA proliferating cell nuclear antigen -3.67987
KIF14 kinesin family member 14 -3.28426
MSN moesin -3.23132
RBM34 RNA binding motif protein 34 -3.20091
MFSD12 major facilitator superfamily domain containing 12 -2.91601
CTNND1 catenin (cadherin-associated protein), delta 1 -2.89022
FASTKD5 FAST kinase domains 5 -2.58761
GPX4 glutathione peroxidase 4 -2.50803
TMEM230 transmembrane protein 230 -2.46842
DDRGK1 DDRGK domain containing 1 -2.45738
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.42984
NLRP4 NLR family, pyrin domain containing 4 -2.4099
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.38974
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.35991
PWWP3A PWWP domain containing 3A, DNA repair factor -2.34486
SEC23B Sec23 homolog B (S. cerevisiae) -2.24987
RGS2 regulator of G-protein signaling 2 -2.1498
CIB1 calcium and integrin binding 1 (calmyrin) -2.01153