CRCGN015_MCF10A.WT.HP_24H:F15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoic acid, sodium 11.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:F15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PKN1 protein kinase N1 4.76975
ZNF586 zinc finger protein 586 4.28666
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.19379
KIF5C kinesin family member 5C 4.07643
UGDH UDP-glucose 6-dehydrogenase 3.91812
CLNS1A chloride channel, nucleotide-sensitive, 1A 3.77653
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.62046
ZNF134 zinc finger protein 134 3.33021
ZNF551 zinc finger protein 551 3.32098
TCTN1 tectonic family member 1 3.0978
THAP12 THAP domain containing 12 2.99294
RSF1 remodeling and spacing factor 1 2.96416
COMP cartilage oligomeric matrix protein 2.93447
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.93116
AAMDC adipogenesis associated, Mth938 domain containing 2.92262
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.90585
ZNF813 zinc finger protein 813 2.86304
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.85432
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.79672
CCNF cyclin F 2.7596
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 2.74332
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.72468
NRBF2 nuclear receptor binding factor 2 2.65295
PDIA5 protein disulfide isomerase family A, member 5 2.609
GCA grancalcin, EF-hand calcium binding protein 2.5643
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.54141
ZNF761 zinc finger protein 761 2.52339
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.51019
BAG4 BCL2-associated athanogene 4 2.49199
GPM6B glycoprotein M6B 2.40604
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 2.37072
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.31616
PTX3 pentraxin 3, long 2.29564
PAAF1 proteasomal ATPase-associated factor 1 2.28815
AGTPBP1 ATP/GTP binding protein 1 2.28663
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.28503
CD302 CD302 molecule 2.28349
MPO myeloperoxidase 2.2694
TFCP2 transcription factor CP2 2.26749
ZNF329 zinc finger protein 329 2.25541
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.19177
SCCPDH saccharopine dehydrogenase (putative) 2.18619
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 2.18012
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 2.17196
ZNF189 zinc finger protein 189 2.15702
SPACA9 sperm acrosome associated 9 2.13057
TLCD3A TLC domain containing 3A 2.08427
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 2.08207
COQ8A coenzyme Q8A 2.06944
TBC1D12 TBC1 domain family, member 12 2.05321
ZNF510 zinc finger protein 510 2.01566
GSR glutathione reductase 2.0123

decreased expression

Symbol Name Standardized Value
OXCT1 3-oxoacid CoA transferase 1 -4.45369
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.23355
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.19765
EXOSC4 exosome component 4 -3.17707
TENT4A terminal nucleotidyltransferase 4A -2.98331
GDF15 growth differentiation factor 15 -2.68026
MOGAT1 monoacylglycerol O-acyltransferase 1 -2.62734
WBP1L WW domain binding protein 1-like -2.56943
TRIB3 tribbles pseudokinase 3 -2.56609
RHBDF2 rhomboid 5 homolog 2 (Drosophila) -2.5416
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -2.53476
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.47438
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.42148
IRS1 insulin receptor substrate 1 -2.41493
PMM2 phosphomannomutase 2 -2.36776
CD79B CD79b molecule, immunoglobulin-associated beta -2.35006
CPED1 cadherin-like and PC-esterase domain containing 1 -2.3219
MRPL46 mitochondrial ribosomal protein L46 -2.29154
UBE2O ubiquitin-conjugating enzyme E2O -2.23562
HMGXB3 HMG box domain containing 3 -2.22894
ISG20 interferon stimulated exonuclease gene 20kDa -2.22487
RBX1 ring-box 1, E3 ubiquitin protein ligase -2.2166
CHPF chondroitin polymerizing factor -2.2134
SARM1 sterile alpha and TIR motif containing 1 -2.19251
PTCD1 pentatricopeptide repeat domain 1 -2.16805
STAG3 stromal antigen 3 -2.1438
PDE8B phosphodiesterase 8B -2.13693
ZNF219 zinc finger protein 219 -2.12043
GNL1 guanine nucleotide binding protein-like 1 -2.08747
RMDN3 regulator of microtubule dynamics 3 -2.08437
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 -2.08102
FOXK2 forkhead box K2 -2.0598
IL21 interleukin 21 -2.05177
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -2.02922
IL3RA interleukin 3 receptor, alpha (low affinity) -2.02741
GSTT4 glutathione S-transferase theta 4 -2.02167