CRCGN015_MCF10A.WT.HP_24H:F17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxymetholone 33.99 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

268 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:F17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 8.63762
HMOX1 heme oxygenase 1 6.8858
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 6.2662
UGDH UDP-glucose 6-dehydrogenase 5.8255
CTSL cathepsin L 5.8241
GLRX glutaredoxin (thioltransferase) 5.60462
SQSTM1 sequestosome 1 5.36899
ADRB2 adrenoceptor beta 2, surface 4.91328
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 4.84358
GCLM glutamate-cysteine ligase, modifier subunit 4.50131
WIF1 WNT inhibitory factor 1 4.14592
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 4.00918
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 3.89916
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.82741
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.79568
NUCB2 nucleobindin 2 3.7856
TSEN2 TSEN2 tRNA splicing endonuclease subunit 3.7611
CBR1 carbonyl reductase 1 3.75811
AGR2 anterior gradient 2 3.69296
PHGDH phosphoglycerate dehydrogenase 3.66123
AKR1C3 aldo-keto reductase family 1, member C3 3.58507
SPAG4 sperm associated antigen 4 3.39256
NQO1 NAD(P)H dehydrogenase, quinone 1 3.31611
FAM114A1 family with sequence similarity 114, member A1 3.29588
LRP10 low density lipoprotein receptor-related protein 10 3.25297
SQOR sulfide quinone oxidoreductase 3.13998
TGFBI transforming growth factor, beta-induced, 68kDa 3.13488
AKR1C1 aldo-keto reductase family 1, member C1 3.10819
HBA1 hemoglobin, alpha 1 3.05927
FOSL1 FOS-like antigen 1 3.03799
ETFB electron-transfer-flavoprotein, beta polypeptide 3.03351
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.01469
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.98088
FHL2 four and a half LIM domains 2 2.97893
KDM5D lysine (K)-specific demethylase 5D 2.96641
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.96182
KEAP1 kelch-like ECH-associated protein 1 2.95903
PRAF2 PRA1 domain family, member 2 2.88384
TUBB6 tubulin, beta 6 class V 2.86389
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.82355
GCLC glutamate-cysteine ligase, catalytic subunit 2.81654
USP9Y ubiquitin specific peptidase 9, Y-linked 2.81408
CCND1 cyclin D1 2.73451
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.67423
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.66203
DUSP4 dual specificity phosphatase 4 2.65765
GMPPA GDP-mannose pyrophosphorylase A 2.6571
PRDX1 peroxiredoxin 1 2.64545
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 2.63457
LOC124907782 dual specificity protein phosphatase 22 2.61495
ELL2 elongation factor, RNA polymerase II, 2 2.58338
GPX2 glutathione peroxidase 2 2.58235
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.56054
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 2.55908
CAPRIN2 caprin family member 2 2.55262
CLTC clathrin, heavy chain (Hc) 2.54808
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.52964
PFN2 profilin 2 2.50328
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 2.47073
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.45105
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.4408
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.43882
COPS7A COP9 signalosome subunit 7A 2.43794
RAP1GAP RAP1 GTPase activating protein 2.42918
ALAS1 5'-aminolevulinate synthase 1 2.36489
BHMT2 betaine--homocysteine S-methyltransferase 2 2.35616
CALU calumenin 2.33924
GARS1 glycyl-tRNA synthetase 1 2.30102
TSKU tsukushi, small leucine rich proteoglycan 2.29272
TALDO1 transaldolase 1 2.28321
IL21R interleukin 21 receptor 2.27805
CEMIP2 cell migration inducing hyaluronidase 2 2.27277
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.26843
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.26574
PPARG peroxisome proliferator-activated receptor gamma 2.25058
CHMP6 charged multivesicular body protein 6 2.23917
MALT1 MALT1 paracaspase 2.22464
FPGS folylpolyglutamate synthase 2.22392
F8A2 coagulation factor VIII-associated 2 2.22245
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.22221
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.21234
RHOC ras homolog family member C 2.20992
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.1966
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 2.19594
ECI2 enoyl-CoA delta isomerase 2 2.19364
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 2.19132
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.19026
CES1 carboxylesterase 1 2.18797
STXBP1 syntaxin binding protein 1 2.18761
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.17866
ODAM odontogenic, ameloblast asssociated 2.17417
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2.166
RRAGA Ras-related GTP binding A 2.1619
ICAM3 intercellular adhesion molecule 3 2.15846
PROCR protein C receptor, endothelial 2.15553
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.15462
TUBG2 tubulin, gamma 2 2.14877
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.14863
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.148
TM4SF1 transmembrane 4 L six family member 1 2.14433
ABHD4 abhydrolase domain containing 4 2.13747
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.13584
FAM50A family with sequence similarity 50, member A 2.13298
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.13136
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 2.12805
TRAF1 TNF receptor-associated factor 1 2.12651
DCBLD2 discoidin, CUB and LCCL domain containing 2 2.11743
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.11169
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.10941
SH2D2A SH2 domain containing 2A 2.10086
ANO10 anoctamin 10 2.09897
SLC75A1 solute carrier family 75 member 1 2.08884
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.08676
EPN2 epsin 2 2.08652
ARCN1 archain 1 2.07707
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 2.06755
SLC67A1 solute carrier family 67 member 1 2.06306
STC2 stanniocalcin 2 2.06155
UBL4A ubiquitin-like 4A 2.06009
LAGE3 L antigen family, member 3 2.05624
RABAC1 Rab acceptor 1 (prenylated) 2.03268

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.95847
WASHC4 WASH complex subunit 4 -5.51985
NUSAP1 nucleolar and spindle associated protein 1 -4.98527
UBE2C ubiquitin-conjugating enzyme E2C -4.92325
KIF20A kinesin family member 20A -4.79061
PRR15L proline rich 15-like -4.33841
CDK4 cyclin-dependent kinase 4 -4.31243
ADI1 acireductone dioxygenase 1 -4.07069
STMN1 stathmin 1 -4.02048
CDK1 cyclin-dependent kinase 1 -3.96522
NCAPD2 non-SMC condensin I complex, subunit D2 -3.84358
OIP5 Opa interacting protein 5 -3.72523
CDCA8 cell division cycle associated 8 -3.55204
PSRC1 proline/serine-rich coiled-coil 1 -3.53831
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.51808
BIRC5 baculoviral IAP repeat containing 5 -3.49061
TOP2A topoisomerase (DNA) II alpha 170kDa -3.47627
UFM1 ubiquitin-fold modifier 1 -3.36997
CD320 CD320 molecule -3.36132
ATG3 autophagy related 3 -3.12106
LBR lamin B receptor -3.10725
DCK deoxycytidine kinase -3.03157
CCNB1 cyclin B1 -3.01383
PLK1 polo-like kinase 1 -3.01383
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.00436
CDC20 cell division cycle 20 -2.91133
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -2.88507
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.85575
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.84669
CCNA2 cyclin A2 -2.83816
CDC25B cell division cycle 25B -2.81282
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.80614
CYCS cytochrome c, somatic -2.7551
FOS FBJ murine osteosarcoma viral oncogene homolog -2.72637
FOXM1 forkhead box M1 -2.7203
NUP88 nucleoporin 88kDa -2.669
IFT22 intraflagellar transport 22 -2.65716
TSFM Ts translation elongation factor, mitochondrial -2.62849
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.60992
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa -2.60266
RNF138 ring finger protein 138, E3 ubiquitin protein ligase -2.59773
PTTG1 pituitary tumor-transforming 1 -2.59121
TMPO thymopoietin -2.58821
NOTCH1 notch 1 -2.58504
PIMREG PICALM interacting mitotic regulator -2.57496
ANKRD55 ankyrin repeat domain 55 -2.52036
KIF14 kinesin family member 14 -2.50989
NEK2 NIMA-related kinase 2 -2.50947
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.50123
HMGB2 high mobility group box 2 -2.49025
DDB2 damage-specific DNA binding protein 2, 48kDa -2.48809
CD58 CD58 molecule -2.48527
EEF1AKMT3 EEF1A lysine methyltransferase 3 -2.4847
GLI1 GLI family zinc finger 1 -2.48215
NDC80 NDC80 kinetochore complex component -2.46911
NLRP4 NLR family, pyrin domain containing 4 -2.46331
PARPBP PARP1 binding protein -2.46043
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.45958
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.45457
HOXC6 homeobox C6 -2.45095
KIF4A kinesin family member 4A -2.44847
GTF2A2 general transcription factor IIA, 2, 12kDa -2.44732
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.44249
SLC35A5 solute carrier family 35, member A5 -2.44133
PNRC2 proline-rich nuclear receptor coactivator 2 -2.44114
CENPA centromere protein A -2.4408
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.43436
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like -2.42589
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.41873
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.41872
MTA2 metastasis associated 1 family, member 2 -2.41721
SMC1A structural maintenance of chromosomes 1A -2.40928
FXYD6-FXYD2 FXYD6-FXYD2 readthrough -2.3969
TTYH1 tweety family member 1 -2.39129
HADH hydroxyacyl-CoA dehydrogenase -2.38761
C1QBP complement component 1, q subcomponent binding protein -2.38566
TROAP trophinin associated protein -2.38148
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.35203
CAPN1 calpain 1, (mu/I) large subunit -2.34802
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.32538
CDC25C cell division cycle 25C -2.32168
NT5DC2 5'-nucleotidase domain containing 2 -2.31034
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.30665
WDR45B WD repeat domain 45B -2.29949
CDC23 cell division cycle 23 -2.29914
ZMYM1 zinc finger, MYM-type 1 -2.29369
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.29254
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.28716
SHROOM2 shroom family member 2 -2.28488
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.28334
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -2.27958
LAMP5 lysosomal-associated membrane protein family, member 5 -2.27829
GDF15 growth differentiation factor 15 -2.2765
MRPL49 mitochondrial ribosomal protein L49 -2.27123
PBK PDZ binding kinase -2.26564
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.24264
PELI1 pellino E3 ubiquitin protein ligase 1 -2.2376
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.23186
EHF ets homologous factor -2.22273
HOXB2 homeobox B2 -2.22006
SCTR secretin receptor -2.20964
SINHCAF SIN3-HDAC complex associated factor -2.20508
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 -2.2018
TSPAN12 tetraspanin 12 -2.19573
TMEM209 transmembrane protein 209 -2.19308
KDM3B lysine (K)-specific demethylase 3B -2.18462
NEMP1 nuclear envelope integral membrane protein 1 -2.17812
SMNDC1 survival motor neuron domain containing 1 -2.17621
CTRL chymotrypsin-like -2.1686
KNTC1 kinetochore associated 1 -2.16234
UBXN8 UBX domain protein 8 -2.15542
ZNF35 zinc finger protein 35 -2.14808
CD163L1 CD163 molecule-like 1 -2.14626
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 -2.14007
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -2.13624
NCAPG2 non-SMC condensin II complex, subunit G2 -2.1348
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -2.13456
ADRA2A adrenoceptor alpha 2A -2.12601
TYRO3 TYRO3 protein tyrosine kinase -2.11431
DNM1 dynamin 1 -2.09926
KIF11 kinesin family member 11 -2.07845
SNX2 sorting nexin 2 -2.07798
CKS1B CDC28 protein kinase regulatory subunit 1B -2.07413
RACGAP1 Rac GTPase activating protein 1 -2.07306
MEPCE methylphosphate capping enzyme -2.07011
NR0B2 nuclear receptor subfamily 0, group B, member 2 -2.06954
KDM6A lysine (K)-specific demethylase 6A -2.06734
VAV3 vav 3 guanine nucleotide exchange factor -2.0507
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -2.04774
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit -2.0477
DLK1 delta-like 1 homolog (Drosophila) -2.04241
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.03803
METTL1 methyltransferase like 1 -2.03695
MMP11 matrix metallopeptidase 11 -2.03099
SCYL3 SCY1-like 3 (S. cerevisiae) -2.02954
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.02768
SHPK sedoheptulokinase -2.0267
LRRC31 leucine rich repeat containing 31 -2.02519
CS citrate synthase -2.02445
FANCE Fanconi anemia, complementation group E -2.02304
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -2.02108
ARID4B AT rich interactive domain 4B (RBP1-like) -2.01533
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.01213
BARD1 BRCA1 associated RING domain 1 -2.01004
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) -2.00648
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.00488
PPP4R3B protein phosphatase 4 regulatory subunit 3B -2.00075