CRCGN015_MCF10A.WT.HP_24H:F18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxymetholone 11.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:F18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KIF5C kinesin family member 5C 6.29474
TXNRD1 thioredoxin reductase 1 5.34014
AGR2 anterior gradient 2 4.59068
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.99417
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.98204
SPAG4 sperm associated antigen 4 3.76741
PDIA5 protein disulfide isomerase family A, member 5 3.38224
FOSL1 FOS-like antigen 1 3.22293
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.12358
SCCPDH saccharopine dehydrogenase (putative) 2.85855
FHL2 four and a half LIM domains 2 2.70506
MSRA methionine sulfoxide reductase A 2.45517
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.44829
HMGA2 high mobility group AT-hook 2 2.42476
DUSP4 dual specificity phosphatase 4 2.31342
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.30616
QSOX1 quiescin Q6 sulfhydryl oxidase 1 2.22486
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.22309
SATB1 SATB homeobox 1 2.18343
CBR1 carbonyl reductase 1 2.13919
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.05841
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.03299

decreased expression

Symbol Name Standardized Value
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.94264
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.91633
PRR15L proline rich 15-like -3.49905
DDIT4 DNA-damage-inducible transcript 4 -2.91504
OXA1L oxidase (cytochrome c) assembly 1-like -2.76412
SMNDC1 survival motor neuron domain containing 1 -2.57987
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.57324
CAPN1 calpain 1, (mu/I) large subunit -2.36369
TSPAN4 tetraspanin 4 -2.36342
DNM1 dynamin 1 -2.24439
UNC119 unc-119 homolog (C. elegans) -2.22513
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.18923
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.16087
RIPOR2 RHO family interacting cell polarization regulator 2 -2.15807
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.13986
BTK Bruton agammaglobulinemia tyrosine kinase -2.1316
DRC4 dynein regulatory complex subunit 4 -2.11664
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.10078
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -2.08374
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.07928
PLXNB2 plexin B2 -2.02992
METTL17 methyltransferase like 17 -2.01675
RAB3A RAB3A, member RAS oncogene family -2.01369
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -2.01081
CALB2 calbindin 2 -2.00518
S100A4 S100 calcium binding protein A4 -2.00426