CRCGN015_MCF10A.WT.HP_24H:F23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1h-1,2,3-benzotriazole 33.61 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

26 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:F23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 4.56654
AGR2 anterior gradient 2 4.52494
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.49187
STAP2 signal transducing adaptor family member 2 3.17962
PDLIM1 PDZ and LIM domain 1 2.89386
TLR4 toll-like receptor 4 2.87037
CXCR4 chemokine (C-X-C motif) receptor 4 2.74005
SOX2 SRY (sex determining region Y)-box 2 2.71554
ABHD4 abhydrolase domain containing 4 2.68117
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.58401
ZNF589 zinc finger protein 589 2.44877
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.39356
STK10 serine/threonine kinase 10 2.30847
MSMB microseminoprotein, beta- 2.13172
STMN2 stathmin 2 2.00066

decreased expression

Symbol Name Standardized Value
PGAM4 phosphoglycerate mutase family member 4 -4.83341
MTERF3 mitochondrial transcription termination factor 3 -3.01462
GADD45B growth arrest and DNA-damage-inducible, beta -2.63995
FBXO7 F-box protein 7 -2.629
PFN1 profilin 1 -2.43605
PMM2 phosphomannomutase 2 -2.27148
HSPA1A heat shock 70kDa protein 1A -2.13588
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.09547
CD320 CD320 molecule -2.07697
PTTG1IP pituitary tumor-transforming 1 interacting protein -2.02966
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -2.00231