CRCGN015_MCF10A.WT.HP_24H:G01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nifedipine 100.97 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

361 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:G01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ALAS1 5'-aminolevulinate synthase 1 4.58906
AGR2 anterior gradient 2 4.57062
PYCR1 pyrroline-5-carboxylate reductase 1 4.55572
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.40825
CCDC92 coiled-coil domain containing 92 4.13106
SNAP25 synaptosomal-associated protein, 25kDa 4.09328
CCP110 centriolar coiled coil protein 110kDa 3.85502
HOXA5 homeobox A5 3.71264
AARS1 alanyl-tRNA synthetase 1 3.66676
NUCB2 nucleobindin 2 3.64654
FHL2 four and a half LIM domains 2 3.59594
GARS1 glycyl-tRNA synthetase 1 3.51996
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.49908
PRAF2 PRA1 domain family, member 2 3.40076
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.36159
BACE2 beta-site APP-cleaving enzyme 2 3.18632
WIF1 WNT inhibitory factor 1 3.16727
KLHDC2 kelch domain containing 2 3.11586
PHGDH phosphoglycerate dehydrogenase 3.05394
SKIC2 SKI2 subunit of superkiller complex 3.02787
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.982
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.95577
GLRX glutaredoxin (thioltransferase) 2.90463
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.88909
XPOT exportin, tRNA 2.88531
CBY1 chibby homolog 1 (Drosophila) 2.84198
STX4 syntaxin 4 2.83178
LRP10 low density lipoprotein receptor-related protein 10 2.82927
LOXL1 lysyl oxidase-like 1 2.78564
TBX2 T-box 2 2.77861
TRIOBP TRIO and F-actin binding protein 2.77646
ABHD14A abhydrolase domain containing 14A 2.77302
PLCB4 phospholipase C, beta 4 2.73051
SYNGAP1 synaptic Ras GTPase activating protein 1 2.69886
PFDN2 prefoldin subunit 2 2.67485
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.66122
EHD3 EH-domain containing 3 2.65981
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.64214
CRELD2 cysteine-rich with EGF-like domains 2 2.63107
SH3YL1 SH3 and SYLF domain containing 1 2.58479
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.58339
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.58327
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.56671
NEFL neurofilament, light polypeptide 2.56281
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.55387
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.55173
TRIB3 tribbles pseudokinase 3 2.53973
CHGB chromogranin B 2.5298
NRIP1 nuclear receptor interacting protein 1 2.52654
PNKP polynucleotide kinase 3'-phosphatase 2.52138
PRKX protein kinase, X-linked 2.51717
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.49873
COPG1 coatomer protein complex, subunit gamma 1 2.4902
CNPY3 canopy FGF signaling regulator 3 2.48464
IFT27 intraflagellar transport 27 2.48275
DUSP6 dual specificity phosphatase 6 2.47731
CUX1 cut-like homeobox 1 2.47429
TMEM94 transmembrane protein 94 2.46792
NIT1 nitrilase 1 2.46516
JMJD1C jumonji domain containing 1C 2.43082
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.4287
CCS copper chaperone for superoxide dismutase 2.41694
ZMAT5 zinc finger, matrin-type 5 2.38815
GSTZ1 glutathione S-transferase zeta 1 2.38293
CSNK1E casein kinase 1, epsilon 2.3729
FGFR4 fibroblast growth factor receptor 4 2.3724
TMEM53 transmembrane protein 53 2.36825
RUNDC3A RUN domain containing 3A 2.35913
CNKSR3 CNKSR family member 3 2.33163
GOLGB1 golgin B1 2.32954
RGS7 regulator of G-protein signaling 7 2.32772
INSL4 insulin-like 4 (placenta) 2.32149
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.31915
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.29293
SYT1 synaptotagmin I 2.29223
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 2.2861
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.28108
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.2791
HOXC5 homeobox C5 2.24202
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 2.24198
TFF1 trefoil factor 1 2.23323
SPATA20 spermatogenesis associated 20 2.23316
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.23142
CREB3L2 cAMP responsive element binding protein 3-like 2 2.23066
IFFO1 intermediate filament family orphan 1 2.22246
ZC2HC1A zinc finger, C2HC-type containing 1A 2.21749
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 2.21641
SLC12A8 solute carrier family 12, member 8 2.21005
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 2.19939
NEFM neurofilament, medium polypeptide 2.19482
MVP major vault protein 2.19273
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.17798
CORO1A coronin, actin binding protein, 1A 2.17267
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 2.16943
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.16562
PCSK1 proprotein convertase subtilisin/kexin type 1 2.16001
P3H3 prolyl 3-hydroxylase 3 2.15951
TRAPPC12 trafficking protein particle complex 12 2.15417
PIAS3 protein inhibitor of activated STAT, 3 2.151
LOC114841035 uncharacterized LOC114841035 2.15015
YIPF3 Yip1 domain family, member 3 2.14947
NARS1 asparaginyl-tRNA synthetase 1 2.14545
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 2.14433
NAP1L3 nucleosome assembly protein 1-like 3 2.14275
DUSP10 dual specificity phosphatase 10 2.13188
SNF8 SNF8, ESCRT-II complex subunit 2.11808
WDTC1 WD and tetratricopeptide repeats 1 2.11315
PKN1 protein kinase N1 2.10649
TSGA10 testis specific, 10 2.10334
COG4 component of oligomeric golgi complex 4 2.10296
CKAP4 cytoskeleton-associated protein 4 2.10054
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.08918
TLR4 toll-like receptor 4 2.08877
INA internexin neuronal intermediate filament protein, alpha 2.08866
DUSP4 dual specificity phosphatase 4 2.08862
HDLBP high density lipoprotein binding protein 2.08573
TYK2 tyrosine kinase 2 2.08318
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.08312
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.0827
RCN1 reticulocalbin 1, EF-hand calcium binding domain 2.07431
DZIP3 DAZ interacting zinc finger protein 3 2.06439
ORAI2 ORAI calcium release-activated calcium modulator 2 2.06096
CUL7 cullin 7 2.06082
APOLD1 apolipoprotein L domain containing 1 2.05543
HDAC4 histone deacetylase 4 2.04983
NFASC neurofascin 2.04323
NALF1 NALCN channel auxiliary factor 1 2.03874
NAIP NLR family, apoptosis inhibitory protein 2.0369
PDE1A phosphodiesterase 1A, calmodulin-dependent 2.0343
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.03376
BBLN bublin coiled coil protein 2.03218
LONP2 lon peptidase 2, peroxisomal 2.03146
TXNL4B thioredoxin-like 4B 2.02265
CLCN4 chloride channel, voltage-sensitive 4 2.0192
NRDC nardilysin convertase 2.00315
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 2.00311
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.00108

decreased expression

Symbol Name Standardized Value
DCK deoxycytidine kinase -7.0818
PLK1 polo-like kinase 1 -6.44564
UBE2C ubiquitin-conjugating enzyme E2C -5.65337
TSPAN4 tetraspanin 4 -5.55482
KIF14 kinesin family member 14 -5.33856
PSRC1 proline/serine-rich coiled-coil 1 -5.09559
MSMO1 methylsterol monooxygenase 1 -4.9744
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.7197
CCNB2 cyclin B2 -4.66249
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.45846
STMN1 stathmin 1 -4.19022
CDK1 cyclin-dependent kinase 1 -4.16006
HAT1 histone acetyltransferase 1 -4.07754
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -4.04998
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.95758
ADRB2 adrenoceptor beta 2, surface -3.87429
ATF5 activating transcription factor 5 -3.8057
KIF20A kinesin family member 20A -3.80416
CDCA8 cell division cycle associated 8 -3.71457
CCNF cyclin F -3.63822
CCNA2 cyclin A2 -3.60992
KIF4A kinesin family member 4A -3.58815
PUF60 poly-U binding splicing factor 60KDa -3.52811
AURKA aurora kinase A -3.50514
TTK TTK protein kinase -3.49655
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.44923
CENPA centromere protein A -3.40857
SMNDC1 survival motor neuron domain containing 1 -3.37422
COG2 component of oligomeric golgi complex 2 -3.33963
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.28318
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.27411
UBIAD1 UbiA prenyltransferase domain containing 1 -3.20077
TPX2 TPX2, microtubule-associated -3.16765
C1QBP complement component 1, q subcomponent binding protein -3.15762
INSIG1 insulin induced gene 1 -3.14977
HJURP Holliday junction recognition protein -3.14687
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.11004
CDCA3 cell division cycle associated 3 -3.06612
CCNB1 cyclin B1 -2.99479
LBR lamin B receptor -2.9821
DEPDC1 DEP domain containing 1 -2.97353
IVL involucrin -2.97067
BIRC5 baculoviral IAP repeat containing 5 -2.96777
TROAP trophinin associated protein -2.96176
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.95758
SCD stearoyl-CoA desaturase (delta-9-desaturase) -2.90044
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.89467
ZNF263 zinc finger protein 263 -2.8913
VANGL1 VANGL planar cell polarity protein 1 -2.88187
ASDURF ASNSD1 upstream open reading frame -2.8798
MIS12 MIS12 kinetochore complex component -2.86235
PBK PDZ binding kinase -2.85994
PI3 peptidase inhibitor 3, skin-derived -2.85451
LGALSL lectin, galactoside-binding-like -2.81707
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.81285
RNF167 ring finger protein 167 -2.8028
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.77528
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.75822
CBR3 carbonyl reductase 3 -2.74986
HMOX2 heme oxygenase 2 -2.7435
MVD mevalonate (diphospho) decarboxylase -2.73556
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.71732
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.69383
CASP8AP2 caspase 8 associated protein 2 -2.69251
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.68678
S100A8 S100 calcium binding protein A8 -2.6829
SH3D19 SH3 domain containing 19 -2.6786
KIF18B kinesin family member 18B -2.6749
USP39 ubiquitin specific peptidase 39 -2.64417
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.63488
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.62976
MCM3 minichromosome maintenance complex component 3 -2.61802
NEK2 NIMA-related kinase 2 -2.6168
ANAPC1 anaphase promoting complex subunit 1 -2.60412
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.59955
CDC20 cell division cycle 20 -2.58492
BORA bora, aurora kinase A activator -2.57751
SPC25 SPC25, NDC80 kinetochore complex component -2.57032
CKS2 CDC28 protein kinase regulatory subunit 2 -2.54819
SPDL1 spindle apparatus coiled-coil protein 1 -2.53833
OIP5 Opa interacting protein 5 -2.52453
KRT10 keratin 10, type I -2.51301
MCM10 minichromosome maintenance complex component 10 -2.51072
NCAPH non-SMC condensin I complex, subunit H -2.48915
NUSAP1 nucleolar and spindle associated protein 1 -2.48537
KIF23 kinesin family member 23 -2.47451
FBXO5 F-box protein 5 -2.47117
HOXB13 homeobox B13 -2.46842
RPP40 ribonuclease P/MRP 40kDa subunit -2.45241
GEMIN2 gem (nuclear organelle) associated protein 2 -2.4463
CCKBR cholecystokinin B receptor -2.44435
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) -2.43877
URM1 ubiquitin related modifier 1 -2.43388
GPR65 G protein-coupled receptor 65 -2.43371
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.43317
PRC1 protein regulator of cytokinesis 1 -2.42596
ANGPTL7 angiopoietin-like 7 -2.42523
LORICRIN loricrin cornified envelope precursor protein -2.42295
LOC128966597 MAL-like protein -2.41654
BARD1 BRCA1 associated RING domain 1 -2.40536
RABIF RAB interacting factor -2.40202
H1-10 H1.10 linker histone -2.39997
BCL7B B-cell CLL/lymphoma 7B -2.39543
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.39292
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) -2.37832
TMX2 thioredoxin-related transmembrane protein 2 -2.37719
KIF2C kinesin family member 2C -2.37455
FASTKD5 FAST kinase domains 5 -2.37083
KRT1 keratin 1, type II -2.36665
RAB5IF RAB5 interacting factor -2.36399
NDC1 NDC1 transmembrane nucleoporin -2.35972
FOXM1 forkhead box M1 -2.34906
FASTKD1 FAST kinase domains 1 -2.34401
SPPL2A signal peptide peptidase like 2A -2.33692
NOL9 nucleolar protein 9 -2.33286
CLDN4 claudin 4 -2.32795
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -2.32663
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.31626
MOCS2 molybdenum cofactor synthesis 2 -2.30538
WDCP WD repeat and coiled coil containing -2.29989
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.28786
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa -2.28662
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.2788
NCAPG2 non-SMC condensin II complex, subunit G2 -2.27579
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -2.26831
S100B S100 calcium binding protein B -2.26743
HSPA8 heat shock 70kDa protein 8 -2.26468
FAIM Fas apoptotic inhibitory molecule -2.26426
TMEM9B TMEM9 domain family, member B -2.26211
MKI67 marker of proliferation Ki-67 -2.26194
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) -2.25529
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.25226
ERCC6L excision repair cross-complementation group 6-like -2.24759
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -2.24494
PALB2 partner and localizer of BRCA2 -2.2442
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.24067
GLRX5 glutaredoxin 5 -2.23352
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.22854
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 -2.22742
NAP1L4 nucleosome assembly protein 1-like 4 -2.22461
TMEM33 transmembrane protein 33 -2.22073
XPA xeroderma pigmentosum, complementation group A -2.21953
NSD2 nuclear receptor binding SET domain protein 2 -2.21545
LOC112694756 uncharaterized LOC112694756 -2.21467
ZNF7 zinc finger protein 7 -2.21111
GDF15 growth differentiation factor 15 -2.20796
MTCH2 mitochondrial carrier 2 -2.20292
LYSET lysosomal enzyme trafficking factor -2.19867
EPPK1 epiplakin 1 -2.19715
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.19164
CALML5 calmodulin-like 5 -2.18708
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) -2.18706
GTF2A2 general transcription factor IIA, 2, 12kDa -2.18667
MOB4 MOB family member 4, phocein -2.1861
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -2.17727
SPRR1B small proline-rich protein 1B -2.17579
QRICH1 glutamine-rich 1 -2.17421
NSUN3 NOP2/Sun domain family, member 3 -2.16488
TMEM11 transmembrane protein 11 -2.16429
ATG5 autophagy related 5 -2.16146
DBF4 DBF4 zinc finger -2.15683
SPRR1A small proline-rich protein 1A -2.15408
SRSF2 serine/arginine-rich splicing factor 2 -2.15251
DSN1 DSN1, MIS12 kinetochore complex component -2.15077
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.15059
TRIP10 thyroid hormone receptor interactor 10 -2.14811
MED7 mediator complex subunit 7 -2.14731
DNASE1L3 deoxyribonuclease I-like 3 -2.13667
RACGAP1 Rac GTPase activating protein 1 -2.13487
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -2.12802
CDKN3 cyclin-dependent kinase inhibitor 3 -2.12557
CYCS cytochrome c, somatic -2.12246
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 -2.12202
RAB27B RAB27B, member RAS oncogene family -2.12179
ZMYM1 zinc finger, MYM-type 1 -2.11753
NCAPD3 non-SMC condensin II complex, subunit D3 -2.11377
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -2.11375
NELFCD negative elongation factor complex member C/D -2.11215
CENPF centromere protein F, 350/400kDa -2.11209
HEXIM1 hexamethylene bis-acetamide inducible 1 -2.11046
FLG filaggrin -2.10773
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -2.10468
SORBS3 sorbin and SH3 domain containing 3 -2.09917
TXNDC9 thioredoxin domain containing 9 -2.09578
DSG1 desmoglein 1 -2.09252
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.09049
SNX6 sorting nexin 6 -2.08327
TMPO thymopoietin -2.07854
EXOSC8 exosome component 8 -2.07687
CCNC cyclin C -2.07539
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.07323
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.07283
CKAP2 cytoskeleton associated protein 2 -2.07156
LDHA lactate dehydrogenase A -2.066
ZDHHC6 zinc finger, DHHC-type containing 6 -2.06509
EXO1 exonuclease 1 -2.06013
ADI1 acireductone dioxygenase 1 -2.05855
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -2.05606
CD34 CD34 molecule -2.05558
STIL SCL/TAL1 interrupting locus -2.05364
MAIP1 matrix AAA peptidase interacting protein 1 -2.05258
LOC124906748 beta-defensin 4A -2.04475
SOAT2 sterol O-acyltransferase 2 -2.0411
LIPT1 lipoyltransferase 1 -2.04101
LMO1 LIM domain only 1 (rhombotin 1) -2.04011
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.03717
TMSB15B thymosin beta 15B -2.03625
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -2.03468
MCM6 minichromosome maintenance complex component 6 -2.03424
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.03066
ATP5MC3 ATP synthase membrane subunit c locus 3 -2.02671
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.02574
HINFP histone H4 transcription factor -2.02195
AURKB aurora kinase B -2.02168
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) -2.02167
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.02146
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -2.0205
HEATR1 HEAT repeat containing 1 -2.01888
CCN5 cellular communication network factor 5 -2.01784
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.0163
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.01354
WTAP Wilms tumor 1 associated protein -2.01154
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.01121
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -2.01066