CRCGN015_MCF10A.WT.HP_24H:G07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-chloroacetophenone 101.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:G07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 3.94993
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.20733
TXNRD1 thioredoxin reductase 1 3.09298
TGFB3 transforming growth factor, beta 3 3.02954
EAPP E2F-associated phosphoprotein 3.02656
COL11A1 collagen, type XI, alpha 1 2.96282
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.66706
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.63161
HBA1 hemoglobin, alpha 1 2.61709
TLCD3A TLC domain containing 3A 2.60295
WIF1 WNT inhibitory factor 1 2.41176
VGLL4 vestigial-like family member 4 2.24576
MBIP MAP3K12 binding inhibitory protein 1 2.06122
ANAPC10 anaphase promoting complex subunit 10 2.05137

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -4.18335
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.13097
THAP11 THAP domain containing 11 -4.05286
HMG20B high mobility group 20B -3.99337
NPDC1 neural proliferation, differentiation and control, 1 -3.87034
YME1L1 YME1-like 1 ATPase -3.74927
TRAPPC3 trafficking protein particle complex 3 -3.42583
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 -3.20625
SLC25A46 solute carrier family 25, member 46 -3.05116
TSPAN4 tetraspanin 4 -3.01059
SLC35F2 solute carrier family 35, member F2 -2.94114
DNM1L dynamin 1-like -2.78929
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.65214
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -2.42387
MRPS15 mitochondrial ribosomal protein S15 -2.33748
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.04454
MVP major vault protein -2.00393