CRCGN015_MCF10A.WT.HP_24H:G09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-chloroacetophenone 11.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:G09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCR4 chemokine (C-X-C motif) receptor 4 4.52596
MEF2C myocyte enhancer factor 2C 4.50681
RAB11FIP2 RAB11 family interacting protein 2 (class I) 4.43833
SSBP2 single-stranded DNA binding protein 2 4.30415
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.35425
PDIA5 protein disulfide isomerase family A, member 5 3.3023
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.74738
IGHMBP2 immunoglobulin mu binding protein 2 2.53209
GMPPB GDP-mannose pyrophosphorylase B 2.35496
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 2.30001
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.3
WDR6 WD repeat domain 6 2.17937
LYRM1 LYR motif containing 1 2.17919
QPRT quinolinate phosphoribosyltransferase 2.14877
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.08304
FAT1 FAT atypical cadherin 1 2.06564
VAV3 vav 3 guanine nucleotide exchange factor 2.05278
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.04753
BCAP29 B-cell receptor-associated protein 29 2.04301
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 2.02088

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -4.82729
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.61531
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.20621
PCNA proliferating cell nuclear antigen -4.15498
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.10241
VDAC1 voltage-dependent anion channel 1 -3.47078
TIMP1 TIMP metallopeptidase inhibitor 1 -3.10946
IPO13 importin 13 -2.90995
C1QBP complement component 1, q subcomponent binding protein -2.49511
TSPOAP1 TSPO associated protein 1 -2.2699
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -2.22737
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.21079
ATP7B ATPase, Cu++ transporting, beta polypeptide -2.14323
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.13353
EPS8L3 EPS8-like 3 -2.12098
GDF15 growth differentiation factor 15 -2.0981
KIF3C kinesin family member 3C -2.09052
TRIB3 tribbles pseudokinase 3 -2.08818
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase -2.08433
TMEM94 transmembrane protein 94 -2.07742
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.06259
LOC102723713 TP53-target gene 3 protein -2.05471
PANK2 pantothenate kinase 2 -2.04351
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.03366
SNRPE small nuclear ribonucleoprotein polypeptide E -2.02732
PFN1 profilin 1 -2.0109